Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.

Endorphins

Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

no sexual desire vitamin to increase testosterone level anti depression meds natural penis enlargement foods stay erect review boost testosterone food who sells viagra best muscle enhancer buy viagra over the counter usa inhouse physicians sore erection stim rx pills unable to get erection erection aid nervous erectile dysfunction prazosin cost huge cock erection que es viril does drinking water help sexually virectin ingredients

weight loss clip art diet pills no workout popular weight loss program magnetic weight loss earrings catelynn teen mom weight loss lysine weight loss tru vision weight loss dr sebi products for weight loss the blue box weight loss chinese weight loss tea does neurontin cause weight loss printable weight loss journal weight loss amphetamine 30 10 weight loss for life reviews zija diet pills weight loss pills alli best natural fat burner supplements weight loss and inches tracker lipodrene elite reviews diet pills that work fast

vape no A Tag

sunset cbd reviews cbd nyc cbd for restless leg syndrome animals functions arthritis cbd broad spectrum cbd vape oil cbd living cbd freeze roll on cbd hotel indie green market cbd buy cbd oil wichita ks cannabis oil for joint pain how many mg of cbd oil for anxiety smok species vitalife cbd oil reviews holland rainbow rose seeds best cbd oil brand for fibromyalgia using cbd oil for arthritis healing nation cbd pure cbd oil legal 2016 does cbd oil make you test positive on a drug screen