Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.


Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

low libido in men can you make your balls bigger wife no sex natural male enhancement pills young men sex i got a boner vine men with low libido make penis bigger can depression cause low testosterone erectile dysfunction solutions what is better viagra or cialis alpha male enhancement whats erection alpha testosterone how to enlarge penis size blue pill with m big and small penis top male enhancement pills running penis testosterone supplement reviews proven testosterone boosters creatine sex drive tek naturals oysters testosterone super male t reviews vidalista 20mg vigrx plus for sale l arginine boners strong antifungal male enhancement herbs what is erectile levitra free sample how to get an erection naturally nugenix cvs horny goat weed blood pressure natural herbs to increase male libido tri mix erectile dysfunction how to keep my penis hard definition for dick male enhancement really work parsley herbal flomax generic name white pill m 10 uncircumcised erect penis penis skin rash prices viagra smallest erect penis biotrust nutrition reviews prescription drug names i need penis nugenix testosterone penis girth average does the bathmate work average penis length america male enhancement omaha extenze tablet

avocado weight loss chicken broth weight loss meal prepping for weight loss best diet for energy and weight loss weight loss md cherry creek medical weight loss doctors near me spokane weight loss clinic ms chunky weight loss drinking water help loss weight adele weight loss 2016 weight loss track sheet weight loss pills for stomach fat dr vactor weight loss reviews weights for weight loss weight loss pills kardashians used mediterranean diet weight loss buttermilk benefits weight loss phentermine and zoloft for weight loss lactobacillus gg weight loss weight loss no sugar harrisburg weight loss center stretch marks after weight loss mens weight loss workout plan tighten skin after weight loss weight loss centers in louisville ky is greek yogurt good for weight loss kim kardashian weight loss plan weight loss subscription box concept 2 weight loss victoza weight loss morning breakfast for weight loss endocrinologist and weight loss weight loss pills for morbidly obese professional weight loss can weight loss pills affect pregnancy pink hearts diet pills weight loss pills scientifically proven great weight loss workouts slim xtreme gold diet pills otc diet pills that give you energy super slim bomb diet pills reviews bydureon weight loss fake diet pills b12 dose for weight loss citrus fit plus diet pills ariel winter weight loss diet pills watchdog raspberry ketone fruta planta diet pills side effects v3 diet pills price gluten free weight loss diet program smoothie diets for quick weight loss diet chart for weight loss pdf boiled chicken diet for weight loss iowa weight loss beat diet pill metabolism booster supplements

vape no A Tag

cbd isolate for sale acne canada cbd oil in dallas clinical pharmacology definition full spectrum cbd oil vs isolate vape pen for cbd oil amazon cbd for horses research best dosage cbd oil rave reviews cbd medici enterprises cbd for gastritis alabama cbd cbd oil for libido charlotts web cbd oil reviews cbd and receptors cbd oil texas drug test cbd sprouts decarb cbd flower reddit liberty lotion cbd were there any cbd polonia water park cbd v cbn best cbd oil organic 7 leaf pot plant hemp me cbd cbd oil volcano vape normal cbd diameter ultrasound i need to know how to watermelon cbd oil trugreen cbd oil hemp fusion 300mg cbd vape oil from verified sellers hemp oil for depression cbd oil shows up on drug test wikipedia thc ibuprofen price walmart pain man where can i buy cbd cream new life hemp oil reviews cbd oil thc how do you say acne in spanish what is cbd and what does it do definition chemical how to take sublingual cbd well significado full spectrum cbd oil review novelty id canada cbd 10 mes safety cbd eye drops for glaucoma can cats take cbd oil for humans is cbd oil legal to sell in wyoming cbd oil for tetanus graves disease and marijuana cbd oil urinary stenosis cbd living