Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.


Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

cbd oil parkinsons cbd clones is cbd oil good for you cvs forest cbd vap oil everything to know about weed cbd antifungal cbd oil anally cbd bronchodilator cbd coffee near me can cbd oil help with sleep mevius cigarettes online is hemp extract cbd can you transport cbd oil across state lines ablis cbd reviews how much cbd oil is sativa cbd oil infographic topical cbd for anxiety hempwork cbd oil cbd oil review for anxiety funky farms cbd cartridge is vaping cbd safe k 101 pill is hemp oil good for pain spanish word for weeds cbd oil and suboxone medical marijuana cons best security system consumer reports ny1 jobs 100mg cbd oil for sale amazing big naturals juul cbd pods hippocampal sclerosis treatment cbd oil alabama 2019 needs products legal side of pain hawthorne effect gateway naturals stress meme cbd oil to replace metformin what does massive mean in slang green roads cbd gummies review how cbd isolate is made cbd oil business plan pdf is cbd oil patentable cbd pure hemp oil 600 review why does cbd oil cost different cbd dose for arthritis

vape no A Tag

berberine weight loss 7 day weight loss pills best fruit for weight loss best fat burner 2019 mens weight loss diets top weight loss pills healthy breakfast foods for weight loss best prescription weight loss pills hca weight loss rhodiola rosea weight loss best workout for weight loss and toning weight loss knoxville chitison weight loss quick weight loss center san antonio tx trufix weight loss leading weight loss pills keto diet weight loss rate diet pills help lose weight body measurement chart for weight loss pill that burn belly fat black seed oil weight loss pictures quickslim diet pills healthy weight loss calculator garcinia cambogia diet pills reviews best weight loss spas beer weight loss diet why does weight loss plateau colonic benefits weight loss collagen peptides weight loss weight loss jobs haystak weight loss weight loss pills for women over 50 big boi weight loss prescription diet pill phentermine pink weight loss pills weight loss is 80 diet censor weight loss pills dandelion for weight loss prescription diet pills online pharmacy belly band for weight loss diet pills chattanooga tn jog for weight loss the best diet pills that actually work diet pills fat burners quick weight loss for women over 50 oprah weight loss surgery quick weight loss center sugar land tx lemon juice water weight loss

finasteride coupon how long does staxyn last buying viagra online canada penies growth super brain pill why do black guys have big dicks pills to get hard fast over the counter how to stimulate a man with ed average flaccid penis size drug for sex tip of my dick how to lose an erection avarage sized penis how to get rid of your sex drive do penis traction devices work viagra melanoma men penis pump alpha male testosterone booster top 10 male enhancement pills what is the active ingredient in cialis best nitrate supplement supplements for ed that work lovely lilith viagra falls mens penis pics himalayan viagra generic viagra pills c1 blue round pill libido increase how do guys get hard enhances libido erection process ultra horny gynecologists in rochester ny viagra buy online does a penis have a bone male sex drive supplements ginger sex diabetes pills side effects do i have low testosterone home made viagra gnc anderson indiana can you make it supple drink walmart natural cures erectile dysfunction size gain pills nizagara pills pemis enlargement erection pills for men