Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.


Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

apple cider vinegar for weight loss are diet pills safe thyroid supplements for weight loss best garcinia cambogia diet pills 60 lb weight loss weight loss after abortion suzy weight loss diet pills white with blue specks 1200 calorie diet plan for weight loss almond and weight loss is sauna good for weight loss quick weight loss after baby vitamin b6 benefits for weight loss toe rings for weight loss weight loss magic soup colonic irrigation weight loss christina perri weight loss weight loss belt walmart weight loss steroids for females stationary bicycle for weight loss weight loss record reduce belly fat pills unexplained weight loss and tiredness katy perry weight loss daily mail weight loss 21 day vegan diet weight loss jennifer hudson weight loss 2017 weight loss for dogs tips tibetan herbs for weight loss quick weight loss without hunger lucy hale weight loss diet ali weight loss pills boots will levothyroxine cause weight loss vanilla protein powder for weight loss weight loss clinics boston weight loss pills with caffeine anorexia weight loss calculator menopause pills for weight loss good weight loss breakfasts mthfr treatment weight loss loss weight fast pills cvs testosterone and weight loss dr oz forskolin diet pills ayds weight loss candy pink bikini diet pills weight loss pills for obese walmart acai berry diet pills weight loss berry pills nv diet pills at walmart superfood diet pills the best diet pills 2017 ear seeds weight loss jennifer lopez weight loss diet best prescription weight loss pills garcinia cambogia 100 pure oils for weight loss keto go pills brent smith weight loss

vape no A Tag

cbd gummy bears popular cbd oil cbd oil alaska cbd gummies review cbd purchase where can i find cbd oil cbd and ra cbd oil vaping dangers caffeine and cbd extracting cbd from cannabis cbd products california cbd infused coffee near me how to use cbd oil for neuropathy making cbd cbd work cbd oil legal in michigan differences between thc and cbd nike cb2 94 cbd cartridge effects mens sleeping cap well cbd and uses econo lodge melbourne cbd gummy drop update can you dab cbd isolate powder is cbd oil legal in the philippines map of cbd sydney how much cbd oil for insomnia tru spectrum cbd als and cbd mg experience dorsal striatum function things high people say snake b effect advanced anti aging solution cannabis rx stock care by design spray e cig mania cbd oil for adhd in kids hemp oil nausea cbd oil dropship cannabis oil vs cancer thoughtcloud cbd reviews nasm reviews cbd costa rica way oil definition what is the difference between rso and cbd oil how cbd is harvested make your own cbd vape juice ambien and cbd oil how to separate cbd from thc cbd oil lowell ma cbd fort wayne how often do i need to take cbd oil difference between hemp seed oil and cbd will cbd full spectrum oil come up on a drug test beboe vape cbd oil feels like xanax cbd suppository for sale

what does labido mean muscle growth forum oxycodone and sex testosterone boosters side effects celexa libido herbal sex stimulants dr pill popper tv 58 pills big penis pump taking viagra without ed how to keep penis healthy viagra pre workout can a mans penis shrink best fruits for erectile dysfunction male supplement reviews blue pill with 100 on it the biggest penis size ejaculation process youtube ginseng sex preventing erections best gnc supplements penis clamps where to buy andro 400 erectile dysfunction specialist doctor top 10 male enhancement erect cat penis should i take testosterone booster cbd oil for erectile dysfunction virility ex male enhancement what is a dick boners on tv how to stay hard longer naturally medicine man hearing remedy ingredients human phallus erectile disfuction sildenafil 20 mg tablet testosterone pills amazon celias male enhancement ed definition is testosterone therapy safe erection problem at 30 pills for penis growth foods to eat for erectile dysfunction how to like sex big benis dht penis lack of drive is hims a scam foreskins problems virility ex pills rashes penis diagra pill men on men in bed walgreen viagra performix super t reviews average penile width king size male enhancement price something extra login