Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.


Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

weight loss over 50 cold laser therapy weight loss top 10 weight loss foods weight loss from not drinking weight loss surgery nashville tn celebrity weight loss secrets weight loss clinic in san antonio is jello healthy for weight loss roni weight loss weight loss machine body measurement chart for weight loss average weight loss on keto weight loss slow cooker recipes child weight loss teas that promote weight loss macro for weight loss medi weight loss reviews 2017 gain weight fast pill cleanse programs weight loss cheap weight loss plans crockpot recipes for weight loss quick weight loss diet plan walking program for weight loss does metamucil help with weight loss yogurt smoothie for weight loss melissa mccarthy weight loss 2015 dulcolax weight loss stories dieters tea for weight loss papaya pills weight loss cheap fast weight loss pills curvelle weight loss pills shirataki noodles weight loss ebay diet pills best ranked diet pills d master diet pills mexico does keto boost work dr phil diet pills female hormones weight loss am300 diet pills best weight loss for men best seller diet pills golo release reviews hcg hormone diet pills roseville weight loss gi pure diet pills quick weight loss katy diet pills that burn fat fast weight loss surgery birmingham al pollen diet pills quick weight loss locations lose weight fast pills for men cayenne pepper water weight loss garcinia xt review meal replacement pills for weight loss

cbd for social anxiety cbd vs kratom cbd beauty cbd and ocd all natural cbd oil is it legal for me to have cbd oil hemptide cbd xrp charlote web cbd disposable cbd vape boneyard cbd kaleidoscope cbd strongest cbd vape juice squib edible cbd oil for pain for sale near me cbd oil cured my cancer puritans pride cbd oil eclipse cbd water best cbd vape juice for pain full spectrum cbd oil vs pure cbd oil does cbd interact with any medications temporary tattoos melbourne cbd cbd oil for dermatomyositis talyoni cbd tincture is cbd same as hemp oil cbd oil and mood swings growing high cbd cannabis fancy lollipops cbd oil for sale wisconsin does cvs have self checkout pure med cbd oil lifeaid review euphoria meaning in hindi the body shop careers whole foods cbd products primary consumer cbd oil solutions weed bust cbd oil for knee pain cbs research charlotte web cbd oil losartan side effects liver is cbd oil legal in us delta fu cbd oil dangers cbd oil farm bill 2018 how to make cbd oil from hemp seeds better days cbd oil cbd vape oil with thc when to use cbd oil acne brooklyn cbd cbd oil compared to hemp oil online pharma cbd best and least expensive cbd oil cbd austin tx

vape no A Tag

increased arousal enhances performance best penis traction device how to arouse a woman by touching her white pill 100 staxyn reviews testosterone levels test viagra substitute over the counter penis health viagra webmd tongkat ali webmd viagra to buy male enhancement pills in jeddah penis extensions flomax purpose big penis supplement pills for sale blue star status gnc penis enlargement food 5 foods that build testosterone penis growth before and after silicone penis injections 6 inch girth common sexual enhancement for her global average penis size fix low testosterone noxitril reviews testosterone boosters at gnc libido max vs extenze do breast enhancement pills work sexual endurance dr phil ed pill ultra core max indian viagra is viagra sold over the counter blood pressure and sex cheap viagra india nugenix ultimate testosterone review cost of viagra in canada penis rash treatment the cost of viagra penis pumps work erection not as hard as before sex enhancer tressless reddit the best sex pill in the world ultimate sex how to get a hard dick world largest cock top male enhancers lady rabbit sex men with very large penises alpha prime elite amazon types of erections vitamin d at walmart boron supplement gnc