Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.


Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

weight loss smoothies express weight loss clinic tyler tx best post workout meal for weight loss spironolactone side effects weight loss vincent herbert weight loss surgery colon pills weight loss drinking green tea for weight loss best probiotics for weight loss 2018 j j smith weight loss juice diets for quick weight loss adderall weight loss in a week gym routine for weight loss best diet for weight loss 2018 fireball diet pills what causes weight loss plateau best protein powder for men weight loss best oils for weight loss honey boo boo weight loss weight loss certificate healthy weight loss pounds per week tren weight loss appendix diet pills best grapefruit juice for weight loss best pill to lose belly fat weight loss wellness center quick weight loss menus weight loss pill commercial will metformin cause weight loss 100 pounds weight loss plan orgain meal replacement weight loss ivy forrester weight loss weight loss symtoms weight loss landing page fiber weight loss do body wraps work for weight loss best exercise quick weight loss weight loss pills with prescription phentermine diet pills drug test weight loss pills that work reviews zumba for weight loss yeast pills for weight loss sletrokor review what are the best pills to lose weight weight loss after birth control pills quick weight loss center commercial 3 day detox recipes for weight loss best diet foods for quick weight loss best dog food for weight loss pickle diet weight loss weight loss diet plans that work alpha lean 7 japanese diet weight loss garcinia pills review white and blue diet pills keto diet pills reviews shark tank marshawn lynch weight loss

vape no A Tag

cbd stock price cbd plant oil cbd and drug tests hemp oil benefits trubliss pure cbd saint jane hemp bomb cbd how to buy stock in cbd oil recept cbd oil how long for cbd vape to work foods that heal you cbd vaping cbd health risks cbd for rls hemp definition cbd oil legal federally all natural lollipops delta botanicals cbd royalty free cbd images green relief cbd capsules being high at work colorado cbd laws have any effect cbd oil tennessee law shikai cbd lotion cbd studies on anxiety cbd coconut oil 100mg spot cbd stock photo scientifically proven all you can eat melbourne cbd effects of cbd edibles dr cbd hemp full spectrum cannabis alternative medicine can cdl drivers use cbd cbd dispensary charlotte hometown hero cbd flower where is cbd sold what does que no mean cheap cbd oil that works body pain tablets charlottes web cbd story medical benefits of cannabis oil can a doctor perscribe cbd oil in ga dr matera nyc how much cannabis oil rich meaning in hindi cb bain property management cbd oil from hemp vs marijuana chill cbd oil flavoured cbd oil does cbd oil affect blood sugar good cbd vape oil reddit floyds of leadville can i be cbd oil reviews que meaning does cbd oil affect heart rate cbd vape effects reddit

how to get viagra all natural ed pills male enhancement pills side effects phalloplasty surgery cost taking clomid home cure for ed best way to cut pills male enhancement xl reviews what can i do for ed xyzal male enhancement penis enlargement stretches doctor asked me to get erect penis enlargement surgery results penis pump increase size super big penis viagra review how big dick diabetes and impotence solutions lower testosterone naturally yellow pill with a on it how do test boosters work hims coupon code essential oils for male enlargement penis width pills that long flaccid cock loria medical male enhancement reviews best vitamins for male libido silicone dicks how to make penis longer naturally sildenafil 100mg price extenze product review drugs com pill goat weed benefits best herbal supplements for ed dick doctors erection during physical viagra how to use the first time wwe divas age herb pharm reviews erection after death mr thicc man uncircumcised penis pics doxazosin mesylate side effects why dont i have a penis vine black snake male enhancement reviews follow me for sex having sex with granny male xtra hard erection supplement oxycodone blue capsule drugs in pill form carb buster pills nugenix ultimate testosterone rhino 7 male enhancement side effects supplements to increase testosterone