Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.


Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

walgreens cbd gummy drop wont open 2500 mg cbd oil can you take cbd oil on a plane treatwell cbd cannabis arthritis balm canada cbd oil terra number purpose of cbd oil slow metabolism pills cbd oil before or after workout blood pressure medical definition organic cbd flower specteum customer service diamon cbd cbd and hangovers zilis ultra cell hemp cbd oil hemp oil facts concentrated cbd vape oil molecule definition for kids lazarus cbd coupon code cbd dispensary where to get cbd oil in texas vaping cbd oil for chronic pain cbd and atorvastatin trippy weed drawing cb oil it is for define arthritis cbd oil reliable sources diabetes definition cbd oil diarrhea reddit receptors meaning dram cbd oil biotransformation pharmacology wi cbd oil marijuana tree pictures cbd oil utah for sale cut short hemp cbd benefits selling doterra on amazon cbd clones for sale pf neurology 500 mg cbd oil healthy u cbd where can you buy cbd oil in colorado how to measure cbd oil charlottes cbd buy medical cbd oil cbd capsules 25mg true terpenes in cbd oil oral gvhd cbd distilley oil review vitamin shoppe cbd gummies garden mills cbd oil amazon customer service email uk

kate upton weight loss meghan linsey weight loss la weight loss bar black cohosh weight loss mick foley weight loss gfriend umji weight loss best beachbody program for weight loss what diet pills have ephedra in them physicians weight loss center review jumpstart weight loss cleanse best prescription weight loss drug giving up diet coke weight loss weight loss laxatives 1 weight loss medi weight loss mobile al costco weight loss shakes weight loss blog women cbd weight loss spray can menopause cause weight loss quick weight loss center diet plan bodypump weight loss shark tank weight loss supplement best weight loss treatment teen weight loss stories vysera weight loss indian lake weight loss cryotherapy for weight loss reviews percentage weight loss weight lifting hair loss extreme weight loss hosts does b12 pills work for weight loss weight loss franchise detox weight loss pills that work barry bonds weight loss popular weight loss pills 2015 centers for weight loss 3x slimming power pills weight loss wellbutrin reviews weight loss slim seduction weight loss pills famous diet pills bikini weight loss pills weight loss pills advertisement most effective diet pills probiotics aid weight loss costco diet pills weight loss infographic most effective otc diet pills greek weight loss true diet pills weight loss medication belviq top best diet pills medical weight loss clinic sample diet metabo choice janessa webb weight loss best natural testosterone supplements imipramine weight loss

vape no A Tag

viagra like pills your dick cant tell the difference pills order online reviews erectile dysfunction meds male pills dick supplements bed and ed average size of a man what is a boost bar pill erectile tissue function hwo to make your penis bigger white pill with m how to make big pines in home pleasure pills bigger dick pills stem cell penis growth how to get a big dick without pills minoxidil reviews penis larger sex pills for men to last longer gnc sex pills vimax performance how long to jelq how to know how big your penis will be swedish made penis enlarger does estrogen increase libido prescription online wikipedia erectile dysfunction penile injection for ed big penies erectile dysfunction pathophysiology define erectile dysfunction medical medium supplements male enhancement mercury drug dr on demand coupon what can i take to last longer in bed spotify opens on startup r tressless girls haveing sex hydromax bathmate foreskins problems how does a dick pump work penis tingle gnc mens vitamins 18 cm penis king size pills for sex herb names for girls what does cock ring do sexual vitality what is longjack nugenix review male low testosterone best prostate supplements review d vs l amino acids male enhancement pills uk door doctor