Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.


Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

cbd for social anxiety king kalm cbd what is the cbd cbd 5000mg cream cbd oil legal in north carolina top marijuanas penny stocks 2018 whole greens cbd oil review x rays sydney cbd rheumatoid arthritis and cbd buy cbd oil san diego cbd oil and strokes is cbd oil illegal in wisconsin hudson valley cbd vapes gone wild how does vaping cbd make you feel smoke shops that sell cbd oil near 93534 printing places melbourne cbd natural partners cbd cbd coupon code 2011 what plant does cbd come from how often do you take cbd oil cytokines in rheumatoid arthritis how to dose cbd oil montana yew tip salve cannabis arthritis pure thc effects what is the active ingredient in marijuana cbd and osteoporosis e liquid recipes clones sunrise cbd does cannabis oil lower blood pressure cbd illinois marijuana cure asthma pure cbd oil no thc medical definition of cancer best cbd capsules for anxiety will cbd make you tired why are liver extracts used in the ames test active vs passive immunity hat is cbd oil and how is it made cbd oil and prograf waterloo iowa cbd oil do all hemp oil contain cbd cbd water reviews cbd oil vape migraines can you buy cbd oil in tn

chia seeds weight loss nuvo diet pills weight loss surgeries weight loss fast without pills weight loss menu planners green tea extract diet pills chrissy metz weight loss pic weight loss rate calculator topamax weight loss side effects bodybuilding hgh bean diet for weight loss dandelion root tea weight loss how much vitamin d for weight loss herbal wonder diet pills vivri weight loss carcinogen diet pills motivational weight loss stories trim fit garcinia cambogia reviews 10000 steps a day weight loss stories where to buy alli weight loss pills average weight loss on adipex steroid for weight loss monique weight loss surgery weight loss before and after photos nutrisystem weight loss reviews dr oz weight loss pills garcinia clonidine side effects weight loss weight loss fitness plans weight loss balloon surgery cost weight loss surgery side effects anorexia rapid weight loss essential oil weight loss recipe actor hurley weight loss garcinia cambogia price perimenopausal weight loss pills fun weight loss games hcl weight loss pills forskolin extract for weight loss breastfeeding and weight loss pills pills to burn fat weight loss pills for diabetics type 1 weight loss juicing plans cost of keto diet pills behavior modification for weight loss 3 day diets for quick weight loss cinnamon weight loss drink

alcohol sex drive cost of cialis vs viagra cheapest generic viagra circle k male enhancement viagra single packs blood penis prescribe viagra white bumps on penile shaft canadian prescriptions by mail define black pill ways to get erect fast number one testosterone boosters penis excersises rhino 7 side effects can you get a bigger penis husband has low sex drive why wont my dick grow best male products pennis pill lack of sex side effects the best testosterone booster at gnc dhea vs testosterone male enhancement pills walmart pandora cp malextra pills can penis get smaller health food store nearby dick on men guys getting hard 1 male enlargement pills top mens sex toys for hims ed male sexual performance male performance anxiety solutions penis size statistics signs of a weak man in a relationship longer lasting sex male libido enhancers nitric oxide booster side effects walgreens sex redemption dogs how much is penis surgery for the dick samurai x pill side effects new vigor reviews massive male plus ingredients

vape no A Tag