Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.


Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

how to enjoy sex more how big is my cock penis pump use can you stretch your penis vigra vs cialis zinc makes me horny erictile disfunction best over the counter male enhancement cialis retail price tea tree oil erectile dysfunction when does your penis start growing l tyrosine gnc my thick cock walmart testosterone booster penis enlargement treatments mv7 male enhancement average black penile length ultimate testosterone booster best gnc products for weight loss fda approved penis enlargement gnc extenze dick train drive angry sex scene sex drive free online what is generic viagra increase penile length viagara coupon men aroused herbs for blood flow brazzers exercise your cock corpora cavernosa and corpus spongiosum viagra for woman define lately medical pills what to do when he loses interest testosterone workout what to take to last longer in bed penis size preferences do midgets have small dicks testosterone and sex bruised penile shaft lady era pills alpha test review yohimbe cream testosterone booster six star revatio online new penis enhancement 7 11 male enhancement pills penis pump for sale suma root bodybuilding male enhancement 36 erectile dysfunction penile injection

difference between cbd and thc canna cigars cbd helps with cannabinoid spray best cbd vape oil for pain does hemp milk have cbd cbd drip gold review cbd hemp oil tincture cbd gummy bears 1000mg plus cbd oil affiliate program how to dilute cbd oil cbd oil cold pressed cbd use for anxiety best full spectrum cbd how to measure cbd isolate cbd oil for nausea and vomiting cbd isolate powder for sale gummy drop not working hemp bombs cbd syrup full spectrum cbd vs isolate how does cbd tincture work cbd drops effects cbd asheville nc does natural grocers carry cbd oil printable map of melbourne cbd australia thc drug definition german cbd oil cytochrome c charge hydrolase example groupon cbd oil rick simpson oil denver definition effect we are made of stardust cbd hash is are how much cbd for back pain world health organization fact sheet strava coffee is hemp oil good for anxiety doe physical form physicians mutual commercial cbd oil for carpal tunnel cbd oil benefits for hair indiana cbd laws best dosage cbd thc oil for pain brain age tas cbd oil 20 benfites chronic pain cbd oil for hpv prop 72 pros and cons will cbd oil help with broken toe that still hurts best cbd juul pods reddit

hypothyroidism weight loss demi lovato weight loss diet 1200 calorie weight loss chia seeds before bed for weight loss juicing recipe for weight loss about diet pills belviq weight loss results buy tapeworm diet pills online fruit juice for weight loss rebel wilson weight loss us weekly alkaline weight loss does cbd help with weight loss sugar and weight loss fast dr oz fasting weight loss idaho weight loss nampa amazon keto pills egg diet plan for weight loss alex guarnaschelli weight loss intermittent fasting fast weight loss keto max pills reviews body transformation weight loss bio pills to lose weight all natural weight loss pills that work weight loss ct quickest working weight loss pills weight loss pill for men safe rapid weight loss pills what foods are good for weight loss doctor oz diet pills t3 weight loss results do diet pills affect birth control weight loss juicing plans prolamine diet pills lemon uses for weight loss top diet pills that work weight loss support groups facebook prescription diet pills online pharmacy jumpstart weight loss diet trufix diet pills reviews thyroid causing weight loss free diet pills for women which fruit is best for weight loss confidence diet pills floating poop weight loss medifast diet pills weight loss hip pain do water pills help u lose weight super quick weight loss quick and natural weight loss weight loss pills for 12 year olds ulta fast keto boost side effects slim 3 in 1 diet pills

vape no A Tag