Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.


Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

weight loss forums weight loss pills mexico 20 lbs weight loss weight loss reality tv shows balloon weight loss surgery weight loss pills safety tattoos before and after weight loss vitamin world diet pills all natural weight loss pills ayurvedic weight loss jerry messing weight loss kids weight loss popular weight loss programs deflate weight loss cortisol weight loss pills best diet for crossfit weight loss protein shake for breakfast weight loss best diet pills on market pooping and weight loss alabama weight loss surgery reviews slim and sassy weight loss program fat predator diet pills lifetime fitness weight loss how much water a day for weight loss people magazine weight loss braggs vinegar for weight loss fifty cent weight loss the most popular diet pills weight loss tests sofia carson weight loss stationary bike weight loss results metformin uses for weight loss actual weight loss pills that work tomato pills weight loss raspberry ketone weight loss pills vegan meal plan weight loss over counter diet pills weight loss spa resorts super slim diet pills reviews quick diets for fast weight loss hcg diet pills reviews adderall weight loss results priyanka chopra weight loss diet weight loss surgery louisiana regal keto reviews best diet for belly fat weight loss pure keto pills meloxicam weight loss

low sex drive symptoms appetite booster supplements sertraline sex drive white oval pill with v on it 101 ways to get high without drugs discharge in penis erection on demand pdf pharmacy2home reviews natural erection remedies how to get testosterone naturally big penis having sex length girth penis enlargement doctors sex positions that increase libido penis science what cause erection ageless male reviews amazon perfect cock size blue mass pills orgasm drug erectile dysfunction vitamins 50 plus sex bystolic erectile dysfunction male enhancement homeopathy sudafed erectile dysfunction black rhino pill review i have a boner sex drive enhancer 2020 how to erect fast purple rhino male enhancement pills walgreens commercial avocado testicle x alpha testosterone booster dick pumping penis peppers does jelking work can you get pimples on your dick measuring your penis swollen penile glans testogen where to buy penis eye viagra street value testro x reviews lack of sex side effects alpha prime elite supplement penis stretching before and after testosterone booster six star review good penis girth

receptra naturals sunday scaries boneyard cbd cbd and curcumin blue harvest cbd cbd 831 salinas sydney city restaurants cbd cannabis how to pass ncaa drug test cbd deal cbd pitch deck producers guild of america top ten cbd oil hemp gummies vs cbd cbd liquid gold 5ml cbd tv inexpensive cbd cw botanicals cbd oil chemical def cbd oil dosage for glioblastoma hemp effects pax era weed chemical compound pure global cannabis cell death associated with inflammation is known as the raw food organic cbd hemp oil sheetrock all purpose joint compound cbd oil peoria il immune system spanish does walmart pharmacy have cbd oil body butter wiki what is cbd ointment cannabis gummies legal cbd oil potency quiet brain oil reviews what does vaping cbd feel like cbd who to trust cheap service apartments in melbourne cbd hemp cbd oil legal in texas cbd oil herx diy cbd oil bath bomb canalux cbd oil california outlook for cbd oil anxiety cbd do hemp hearts work like cbd oil a pain management micromist cbd oil make out

vape no A Tag