Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.

Endorphins

Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

natural male libido enhancer erection pump implant increase in libido tips for better erection home remedies male enhancement finasteride coupon supplements containing sildenafil definition labido cold medicine reviews does androzene work pills to make me last longer in bed small penis vs big penis lengthen penis viagra like products your penis hard time getting an erection male erect penis goat weed side effects what does a weiner look like where can i buy andro 400 how to get a wider penis effective testosterone booster average penis size for americans mr benga cock favorite penis size best supplements for sex drive what does boosting testosterone do where to get male enhancement pills gnc website male ed clinics near me pill ms 60 penis cancer symptoms fxm male enhancement over the counter acne pills cvs phallocare male enhancement do jelqing work penis expansion gif early signs of erectile dysfunction teenage male penis penis numb super long dick intracavernosal injection therapy health store nearby red lips male enhancement pills hims chicago desire den sup reviews penis size blogs

plus cbd oil review cbd oil purity cbd extraction equipment charlottes web cbd oil drops cbd and testosterone charlotte web cbd oil reviews hempzilla cbd does cbd cause positive drug test cbd oil and neuropathy best hemp cbd oil for pain states with legal cbd lidtke cbd cbd oil gel capsules cbd tincture dosing 90 day cbd challenge reviews pharma cbd oil thc cbd pain cream virtual office melbourne cbd hotels with balcony melbourne cbd serviced apartments melbourne cbd cbd living water mg cbd oil for hs the healing canna purest cbd oil on market does cbd make you less high how to get authentic cbd oil nih supply store is cbd covered by medicare buy savitex cbd oil cost at k botanicals hemp oil cancer cure snopes marijuana pros and cons is cbd oil good for inflammation holistapet cbd phospho p38 best cbd cream for arthritis what effect does this have cbd legal in minnesota what cbd strain is best for anxiety cbd iai is cbd better than hemp oil best cbd supplements most reasonable site for cbd oil cannabinoid thyroid sioux falls cbd oil cbd oil and vyvanse cbd oil to help you sleep cbd and kratom

vape no A Tag

fast weight loss pills weight loss diet plan for men pdf tequila weight loss green smoothie detox weight loss castor oil pack weight loss brian kelley weight loss strict weight loss diet johns hopkins weight loss 2500 calorie meal plan for weight loss healthiest vegetables for weight loss pool workout for weight loss easy meal prep recipes for weight loss weight loss in child does bupropion cause weight loss low carb diet and weight loss neal boortz quick weight loss carrots and weight loss maximum weight loss workouts charlize theron weight loss diet death weight loss beginners meal plan for weight loss weight loss blog with pictures ww weight loss stories bariatric weight loss chart whole foods weight loss supplement beth chapman after weight loss dr vactor weight loss juice diet recipes for weight loss plan best weigh weight loss weight loss diet plan women transformation weight loss tulsa robert hesse weight loss weight loss plateau help weight training for weight loss enzymes pills weight loss how to drink green tea for weight loss cocaine weight loss pills mediterranean diet weight loss reviews ali weight loss pills boots herbalife diet pills reviews mexico diet pills redotex h3h3 weight loss apidextra diet pills weight loss tattoo ideas safest diet pills over the counter amphetamine weight loss what is this pill used for weight loss sleeping pills