Find us on:

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependencies. It is marketed under the trade names ‘Revia®’ and ‘Depade®’ and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependency.

The term ‘LDN’ refers to the use of Naltrexone at doses below 10mg per day. Naltrexone exhibits novel and paradoxical effects when administered as these low doses, as discovered by Dr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University, in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial using LDN for Crohn's Disease were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

Further studies and research can be found here.

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.

Endorphins

Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

Low Dose Naltrexone (LDN) is being used as a regulator of the immune system, providing relief to patients with autoimmune diseases, and central nervous system disorders. Whilst it is not licensed by the FDA specifically for these conditions, physicians are permitted to prescribe LDN ‘off-label’ for treatments they think are appropriate.

The apparently diverse conditions in which LDN appears to have a therapeutic effect are united by their ability to benefit from increased levels of endorphins (naturally occurring opioids – specifically OGF).

In the interests of promoting further research into different uses of LDN, we encourage LDN users who are willing to be identified to share their experiences with LDN by clicking on Submit Your Story.

Examples of the successful use of LDN, supported by studies as well as reported by patients to date, include the following conditions:

lisa lampanelli weight loss bronchiectasis and weight loss top protein powders for weight loss college weight loss this is us star weight loss extreme weight loss meal plan wellbutrin 450 mg weight loss pentatonix weight loss khloe kardashian weight loss diet bupropion weight loss dosage chandler weight loss season 6 7 weight loss plateau diet tdee weight loss simple weight loss meal plans liquid chlorophyll weight loss thyroid medicine and weight loss when will i see weight loss results mediation for weight loss hemp hearts weight loss healthy diet for women for weight loss ideal breakfast for weight loss transformations weight loss clinic gabriel iglesias weight loss 2019 bob from biggest loser diet pills ulcer weight loss weight loss adipex best post workout drink for weight loss weight loss pills from japan best weight loss probiotic weight loss and metformin sleep and weight loss facts global weight loss weight loss trio young living rick warren weight loss kirsten storms weight loss 2017 kardashian weight loss diet weight loss by not eating louisville weight loss centers new weight loss drugs 2016 best fat burner for weight loss liposuction pills weight loss cannabis for weight loss best weight loss pills with exercise buy diet pills diet pills chattanooga tn carb counting diet for weight loss phentermine diet pills online cheap slimline diet pills non prescription diet pills that work herbs that promote weight loss top 10 diet pill best cleanses for weight loss and detox natures made sleep reviews rob kardashian weight loss 2017

what does cbd feel like reddit bipolar cbd high cbd low thc strains new cbd diabetes and cbd oil cbd anti cancer will cbd show in drug test cvs selling cbd shark shock cbd non psychoactive drugs cbd oil dosage for adults cafe sydney cbd making cbd lotion edible cbd luckys market cbd motion sickness cbd oil cbd in drinks michael rosenbaum cbd oil pain relief cbd select cbd reviews cbd ireland light sensitivity anxiety cbd vape oil effects cbd for arthritis amazon cbd logistics can weed give you diarrhea free cbd vape sample is vaping cbd bad apartments in brisbane cbd for rent who owns cbdmd define compound melb cbd accomodation aa 1439 wellness pro plus cannabis mct oil cbd oil vape utah what is the meaning of ease terra address cbd living water coupon code cbd oil for pain cbd oil vape for sale hemp harvesting equipment cbd oil black friday deals cbd oil while nursing cbd oil ratio can cbd oil help with headaches does cbd oil help parkinsons tremors mr delivery jhb cbd cbd oil and colds cbd oil weslaco tx is cbd oil a pharmaceutical washington state cbd laws is cbd oil legal in wisconsin july 2018 cbd credit card processors

sex drive vitamins plastic surgery penis does birth control lower libido black sex androderm reviews testofuel reviews penis pump safety anime public sex buy staxyn online anti viagra side effects of ed drugs potency man how long for levitra to work micropenis erect penis enlargement technique natural alternative to viagra how to jelq for length pennis size increase medicine what foods make your dick grow natural alternative to vyvanse grower cock best male performance enhancement pills pine biotech penis identification whats my penis name head of dick overactive sex drive how to make a man desire you watch sex drive online free big dick cock ring viagra for hypertension viagra coupon code herbs to increase circulation average pinis size testo max for sale active con test freak enlarge your breasts testofuel gnc how to make your penis larger best male sex enhancement supplements when did viagra go generic short term memory supplements what class of drug is viagra increase semen production supplements to increase ejaculate men shooting big loads how to improve your sex drive vaso 9 male enhancement take your pills review v max male enhancement formula i need a bigger penis male enhancement alpha q erotic doctor visit

vape no A Tag