Find us on:

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.

Endorphins

Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

folic acid benefits weight loss whittier weight loss progressive weight loss is biking good exercise for weight loss max estrada weight loss healthy spices for weight loss weight loss clinic in jackson ms doctor oz diet pills that work weekly weight loss does citalopram cause weight loss healthy weight loss detox no diet weight loss pills waist trainer weight loss results beets weight loss best diet plan for quick weight loss ortho tri cyclen weight loss saturated fat weight loss healthy protein bars for weight loss weight loss clinics oklahoma city vegan recipes weight loss fenugreek pills for weight loss new directions weight loss flat belly diet pills wendy williams diet pills zhen diet pills best otc diet pills

red riding hood cbd oil cbd legal in tennessee does cbd thin your blood marys medicinals transdermal patch metagenics cbd oil cbd for asthma citrus cbd cbd oil reduce inflammation cbd dosage for stroke victims papa and barkley cbd oil cbd dabber hs wholesale cbd cbd oil from canada to us cbd oil kona hawaii restaurants in the melbourne cbd best cbd oil for children payment processing for cbd natural wellness cbd oil who we are how many hemp plants per acre what are the health benefits of cannabis oil nicola murray cbd oil cvs and cbd oil charlotte web cbd oil autism dose cbd oil dot testing friendly cbd 30 mg

vape no A Tag

herbal sexual in 2 deep male enhancement newest ed treatment vasodilator supplement typical cialis dose horny goat weed herb how to make your dick smaller penis jelq herb viagra amazon red mark on penis penis silicon injections male enhancement exercises ballooning how was viagra discovered do kegels work for guys one penis policy engorged penis how to make a girl have sex male review near me what a sex what does it feel like to have a penis energy pills walgreens rhodiola rosea gnc free bottle of nugenix closest thing to viagra evl test reviews how to increase penis size naturally