Find us on:

In order to understand how LDN works, it is crucial to briefly introduce the workings of the ‘natural opioid’ (endorphin) system.


Endorphins are opiate-like molecules produced naturally in the body. The term ‘endorphin’ comes from ‘endogenous morphine’, meaning that it is created within the body, and differentiating it from opioids that are administered from external sources.

Endorphins are produced in most cells in the body, and are important regulators of cell growth, and therefore the immune system. Disorders of the immune system can occur with unusually low levels of these endorphins. The particular endorphin that has been found to influence cell growth as well as immunity is called Opioid Growth Factor (OGF) or Met-Enkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body’s cells. It does this by binding to a receptor on the surface of the cells. The receptor to which OGF binds is the ‘Opioid Growth Factor Receptor’ (OGFr) – previously known as the Zeta (ζ) receptor.

Thus, for the endorphin system to be fully functional, two elements are required: opioid production and cell interaction.

Naltrexone Stimulates the OGF Receptors Producing Therapeutic Effect

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins which were previously bound to the receptors. Specifically, by binding to the OGF receptors, it displaces the body’s naturally produced OGF.

As a consequence of this displacement, the affected cells become deficient in OGF and three things happen:

  1. Receptor production is increased, in order to try to capture more OGF.
  2. Receptor sensitivity is increased, also to try to capture more OGF.
  3. Production of OGF is increased, in order to compensate for the perceived shortage of OGF.

Since LDN blocks the OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect; in which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the elevated endorphins produced as a result of the rebound effect can now interact with the more-sensitive and more-plentiful receptors and assist in regulating cell growth and immunity.

Low Dose Naltrexone (LDN)

The duration of the rebound effect varies from individual to individual, but generally persists for about one day.

The benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of Naltrexone or using a timed-release formulation will result in continuous blockade of OGF receptors, and the rebound effect will not serve any useful purpose.

In scientific terminology, the use of regular-dose Naltrexone results in ‘continuous opioid receptor blockade’ whilst the use of LDN results in ‘intermittent opioid receptor blockade’. In order to benefit from the rebound effect and achieve the therapeutic benefit of LDN, it is essential to avoid timed-release (or slow-release) versions of Naltrexone.

Individuals vary in their metabolic speed and this will result in inter-patient variation in the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. Whilst a single daily dose of between 3mg and 5mg will be suitable for most patients, individual modification of dosage or frequency is sometimes needed.

weight loss: kettlebell swings weight loss b12 injections for weight loss nikki bella before weight loss temecula weight loss best weight loss pre workout ginger water and weight loss tricare weight loss surgery keto ultra pills reviews natural weight loss pills for men homemade weight loss shakes recipe homeopathy weight loss pills how much hcg to take for weight loss pearl weight loss pills weight loss tests 3 day diet pills weight loss slow cooker recipes cheat diet pills e z weight loss pills 30 day diet pills side effects best diet pill shredder diet pills golo diet pills quick easy weight loss plan weight loss during menopause quick healthy weight loss diet plan gnc energy and metabolism weight loss weight loss with gluten free diet nuvoryn weight loss pills reviews otc appetite suppressant fda approved diet pill performix pills super effective weight loss pills

vape: beard vape the one evergreen vapor firefly vape pen wis xname better than vaping best 4 battery vape mod ssv vape nathan vapor airess beyond vape coupons ecig juice dothan al 3 in 1 e cigarette e cigarette vs real cigarette used stats ecig weed vape what are the dangers of vaping is it safe to charge an ecig overnight dying from vaping pistol grip vape best high watt box mod mini e cigarette atomizer vuse e cig ingredients cola man ejuice steep e liquid e cigarette worldwide shipping subtank mini capacity e cigarette bellingham wa smok guardian 40w vegetable vape juice smok h priv with tfv8 how to vape tricks voopoo drag mini fit mode clean vape voopoo too replacement door best dripper for flavour

male enhancement: best exercise to boost testosterone blue energy pills extremely large penis normal erect size how a cock ring works t bomb 3xtreme reviews shea butter for penis ultimate male enhancement 5 sizes penis pill shape average white man penis size types of erections safe testosterone booster ways to masturebait extenze male enhancement improve male orgasm red pill with i 2 viagra side affects best male sex toy 2020 watermelon penis red pills blue lack of sex depression is horny goat weed safe rogaine reviews trouble in spanish vitamin d3 benefits for men unable to maintain erection how big is a large penis wwe supplements how long viagra lasts intramax male enhancement how to please a man with ed

cbd oil: young living cbd oil trends in neurosci benefit of cbd oil find out where you are from select cbd patch everything you need to know about drugs cannapresso cbd evolve cbd do jobs test for cbd where to buy cbd oil in brighton mi take the l cbd wellness appleton take not cbd oil for knee injury spa room essential oil how much cbd oil orally under tongue juice aro cbd oil muscle spasms cbd in olive oil doctor who aliens what does cbd oil do for your body full spectrum cbd oil wholesale neurotin cbd oil select cbd tincture review 2 drops of cbd oil under tongue doterra retail store locations can you take cbd oil into spain cbd oil cannabidiol for pain relax full spectrum cbd vape oil how to make thc oil cbd oil mitbbs hemp oil cures cancer and other diseases