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An estimated 85 million people suffer from skin disease in the U.S. alone! In fact, 1 in 4 Americans have been treated for a skin disease and 50% of the US population over age 65 has not one but two skin diseases.

Doctors are increasingly using LDN and reporting its success in relieving difficult-to-treat skin conditions. As of November 2019, more than 26 reports have been published in the scientific literature about using LDN to treat skin conditions. Below you will find highlights from those reports.

Two skin conditions that have been the subject of many publications are:

Hailey-Hailey Disease (HHD)

Over a dozen(!) reports have been published about using LDN for Hailey-Hailey Disease, also called “benign familial pemphigus.” HHD is a genetic condition that causes painful blisters and skin erosions, infection, and medical complications that severely impact quality of life. Physicians have reported cases of HHD responding well to LDN even when resistance developed to other treatments.

Psoriasis (including subtypes Erythrodermic, Guttate, Vulgaris)

Physicians have published a number of reports on treating psoriasis with LDN. A new study will be published soon by Dr. Leonard Weinstock, affiliated with Washington University School of Medicine, so make sure to subscribe to our updates and be first to know. Our 2019 interview with Dr. Weinstock about LDN's potential as a treatment for psoriasis and psoriatic arthritis gives a preview of coming attractions from his upcoming article.

Of all the articles published about using LDN for treating skin disorders, the following themes tend to run through them all:

  • The skin disease was resistant to "conventional therapies." Disease symptoms (pain, itching, etc.) were still not adequately controlled.
  • Side effects from other treatments were intolerable.
  • LDN was used by itself or added to patients’ other medications.
  • LDN caused the skin condition to go into remission and reduced painful, uncomfortable symptoms.
  • LDN significantly improved quality of life.

Here are some highlights from the published reports about the following conditions:

Amyopathic Dermatomyositis (ADM): "LDN has emerged as an alternative treatment option for patients owing to its efficacy and limited toxicity as seen in the treatment of several autoimmune dermatologic conditions including our case of ADM."

Alopecia: "...LDN would be a possible alternative to be added to the therapeutic arsenal owing to its anti-inflammatory properties, analgesic potential, low cost, and few adverse effects described."

Darier Disease (DD): "...patients with a mild to moderate form of the disease did show a good response."

Dermatitis Herpetiformis (DH): "The patient’s skin lesions were present for 2 years and went into complete remission within 3 months of taking low dose naltrexone."

Dermatomyositis (DM): "The first patient experienced improvement of his skin lesions, arthralgia, and muscle pain. The second patient experienced relief from her recalcitrant pruritus. Despite tapering the other immunosuppressants, her skin disease did not recur..."

Lichen Planopilaris (LPP): "This is the first case series demonstrating the beneficial effects of low-dose naltrexone for patients with LPP. This medication was well-tolerated by the patients and is cost-effective."


An Important Perspective: The Patient’s View

What about the patients' point of view on using LDN for skin diseases? Here are some altruistic LDN users who generously shared their experiences of using LDN for their dermatologic conditions:

Lichen Sclerosis: "After 11 months of LDN, my skin condition has healed 99%. To me, that is nothing short of a miracle!" - Ruth Eisenberg

Psoriasis/Psoriatic Arthritis
"I was diagnosed with Psoriatic Arthritis in 2012...Since taking LDN my life has improved drastically for the better. My joint pain reduced hugely after just 3 days. I sleep much better, and I also find it helps with fatigue and anxiety problems. Low Dose Naltrexone has given me my life back...." - Sarah Berry
"I have been 100% painless, I have lots of energy and I sleep well...My life has completely changed and I'm eternally grateful. I don't use any other drugs than LDN." - Anette Møberg

Eczema (Dermatitis): "It was a miracle and a lifesaver!" - Tom Jacobs

Pyoderma Gangrenosum: "We saw improvement straight away. The pain went away and I was able to reduce the steroids. When I came off the steroids completely, I went red all over...but the LDN cured that in three days. My thighs have improved greatly and the rest of me is completely clear. I feel happy and full of energy." - Michele Romano

If you or a loved one has a skin disorder, discuss LDN treatment with your healthcare practitioner. If you need help finding an LDN prescriber, LDNscience’s highly popular Prescriber Directory is a useful resource to find an LDN prescriber near you.

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