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Hashimoto’s thyroiditis is an autoimmune disorder involving the thyroid, a gland located at the base of the front of the neck. The thyroid gland produces essential hormones which regulate many body processes including metabolism, growth and development, proper functioning of the heart and nervous system, and reproduction. Proper functioning of every cell of the body is dependent on the hormone produced by the thyroid, T4 (thyroxine), which is subsequently converted in the body to the active thyroid hormone T3 (tri-iodothyronine).

In Hashimoto’s, antibodies are made against the person’s own thyroid gland. It typically progresses slowly over many years, causing chronic damage to the thyroid. This damage results in reduced production of thyroid hormones, called hypothyroidism, which is the cause of its typical symptoms. These symptoms can include fatigue, cold sensitivity, constipation, dry skin, brittle nails, hair loss, weight gain and depression, among others. Hashimoto’s is the most common cause of hypothyroidism in the U.S.


Risk factors for Hashimoto’s include female gender, middle age, heredity, the presence of other autoimmune disorders and exposure to radiation.

Hashimoto’s is associated with enlargement of the thyroid gland as it tries to make more hormone as well as an enlarged heart and can result in birth defects, if left untreated in pregnant women.

Hashimoto’s is diagnosed based on testing the blood for thyroid hormone levels and the presence of antibodies against the enzyme, thyroid peroxidase, used in the synthesis of thyroid hormones. The common medical treatment is thyroid hormone replacement.

There is currently no published clinical research about the use of low dose naltrexone (LDN) in Hashimoto’s, however, based on its effectiveness in other autoimmune disorders, many people have found it to be very helpful. Standard treatment, replacement of thyroid hormone for life, helps with symptoms, but neglects to target the underlying cause of the disease. As LDN is known to modulate the immune system by acting on endorphin receptors which play a vital role in immune function, it can possibly subdue the immune reaction and slow down destruction of thyroid cells. It has been widely reported by patients taking LDN who are also on thyroid replacement medication that they can often lower their hormone dosage as the immune-normalizing effects by LDN slow down the autoimmune process.

Learn more about LDN’s mechanism of action here.

Ten Years of Uncontrolled Hashimoto's: A Wild Ride Became Smooth With LDN

Vivienne SmithVivienne Smith

Vivienne Smith was diagnosed with Hashimoto’s and despite maximum doses of thyroid replacement hormone, she couldn’t get out of bed sometimes and on other days she felt “wired”. After suffering for ten years, she took it upon herself to explore other treatment options and found information about low-dose naltrexone on the internet. Vivienne spoke to her doctor about it and she agreed to prescribe it.

After using LDN for only 3 weeks, Vivienne began noticing real improvement. She had more consistent energy, was able to deal with stress better and began going out and exercising. Her work improved and she stopped losing her hair. Vivienne told LDNscience that LDN truly changed her life.

Patient Success Stories

Steve’s thyroid antibody level dropped by 30% after using LDN for other purposes. He says “Take back your life” with LDN!

For Jane every day was difficult and painful due to her Hashimoto’s. She then tried LDN for and it “helped tremendously”! She was able to “continue doing what I need to do each and every day”.

Lesa was diagnosed with Hashimoto’s and LDN was prescribed by her doctor. After one month on 4.5 mg daily, she found it was a “miracle drug”. She went from dragging herself up her front steps at the end of the day to going out dancing again. Lesa states that LDN gave her life back.

After using LDN, Heather’s thyroid laboratory test results normalized.

Carol’s anti-thyroid antibody level was over 3000 and became “undetectable” within 8 months after taking LDN.

After starting LDN, Anne was able to lower her thyroid medication dosage and has “lots of energy and antibodies are heading towards normal”.

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