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Pilot study of tolerability and safety of opioid receptor antagonists as novel therapies for chronic pain among persons living with HIV with past year heavy drinking: a randomized controlled trial
Research Type Human Reported as Clinical Trial Date March 07, 2021 Authors Sally Bendiks, Debbie M. Cheng, Elena Blokhina, Marina Vetrova, Elena Verbitskaya, Natalia Gnatienko, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet & Judith I. Tsui Institution Boston University, First Pavlov State Medical University, NIAAA, V.M. Bekhterev Nat Med Res Ctr; University of Washington Disease Alcoholism, HIV
Pain is common and associated with substance use among persons with HIV (PWH), yet limited management strategies exist. We assessed the feasibility, tolerability, and safety of low-dose naltrexone and standard dose nalmefene to treat chronic pain among PWH with past-year heavy alcohol use in a randomized, double-blinded, 2-arm study (planned enrollment 8 per arm). Participants were recruited in St. Petersburg, Russia between May and October 2018 and randomized to receive either nalmefene (16 m...
The Effects of Low Dose Naltrexone on Opioid Induced Hyperalgesia and Fibromyalgia
Research Type Human Reported as Case Report/Series/Restrospective Study Date February 16, 2021 Authors Daniel Jackson, Sunita Singh, Yanli Zhang-James, Stephen Faraone, Brian Johnson Institution SUNY Upstate Medical University Disease Fibromyalgia, OIH (Opioid Induced Hyperalgesia)
OBJECTIVES: While opioids temporarily alleviate pain, the overshoot of balancing pain drivers may increase pain, leading to opioid induced hyperalgesia (OIH). Our goal was to find out what chronic opioid treatment does to pain tolerance as measured by the cold pressor test (CPT), an objective measure of pain tolerance, and to find an alternative effective treatment for chronic pain and FM. MATERIALS AND METHODS: The setting was an academic addiction medicine service that has an embedded pain se...
Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway.
Research Type Lab (in-vitro) Date February 01, 2021 Authors N Liu, L Yan, F Shan, X Wang, N Qu, MK Handley, M Ma Institution China Medical University, Cytocom Inc. Disease Cancer (general), Cervical Cancer
The incidence of cervical cancer is increasing annually worldwide. Low-dose naltrexone (LDN) has been reported to delay tumor progression, but the mechanism remains unclear. Here, we found that low-dose naltrexone could upregulate the expression of OGFr. Additionally, LDN could suppress the abilities of colony formation, migration and invasion in cervical cancer cells. LDN could also inhibit cervical cancer progression in mice model. Moreover, LDN indirectly reduced the expressions of PI3K, pAKT...
Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer
Research Type Human Reported as Review Date January 26, 2021 Authors RD Couto, BJD Fernandes Institution Federal University of Bahia Disease Cancer (general)
Naltrexone (NTX) is an opioid antagonist that inhibits cell proliferation in vivo when administered in low doses. Naltrexone in low doses are able to reduce tumor growth by interfering with cell signalling as well as by modifying the immune system. It acts as an opioid growth factor receptor (OGFr) antagonist and the OGF-OGFr axis is an inhibitory biological pathway present in human cancer cells and tissues, being a target for treatment with naltrexone low-dose (LDN). Clinical trials have propos...
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with Neuropathic Corneal Pain
Research Type Human Reported as Case Report/Series/Restrospective Study Date January 12, 2021 Authors G. Dieckmann, MC Ozmen, SM Cox, RC Engert, P. Hamrah Institution Tufts University School of Medicine Disease Neuropathic Corneal Pain
PURPOSE: Neuropathic corneal pain (NCP) is caused, by damage or disease of the somatosensory nervous system that innervates the cornea and presents with symptoms of pain or persistent unpleasant sensations, such as burning, dryness, or light sensitivity. This retrospective study aims to assess the efficacy and tolerability of low-dose naltrexone (LDN) in refractory NCP patients. METHODS: Fifty-nine NCP patients with a centralized component treated with oral LDN 4.5  mg at bedtime for at ...
Improvement in Hailey–Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report
Research Type Human Reported as Case Report/Series/Restrospective Study Date December 25, 2020 Authors Darosa Lim, Annie Belisle, Sandra Davar Institution Centre Hospitalier de l’Université de Montréal Disease Hailey-Hailey
Hailey–Hailey disease is a rare autosomal dominant acantholytic disorder due to mutation in the ATP2C1 gene and presents with flaccid blisters in intertriginous regions. Its chronic and relapsing course may negatively impact patients’ quality of life. Multiple medical and interventional treatments have been described with various efficacy. Low-dose naltrexone and oral magnesium chloride represent emerging treatments. Sustained improvement in Hailey–Hailey disease has been reported with the...
Naltrexone's Impact on Cancer Progression and Mortality: A Systematic Review of Studies in Humans, Animal Models, and Cell Cultures
Research Type Human Animal Lab (in-vitro) Reported as Review Date December 18, 2020 Authors Karina Liubchenko, Kevin Kordbacheh, Nika Khajehdehi, Tanja Visnjevac, Frederick Ma, James S. Khan, Myles Storey, Alaa Abd-Elsayed & Ognjen Visnjevac Institution Western University Schulich School of Medicine; 2Bloor Pain Specialists, University of Toronto Mount Sinai Hospital, University of Wisconsin-Madison, McMaster University Disease Cancer (general)
BACKGROUND: Naltrexone (NTX) is an opioid antagonist traditionally used as a treatment for alcohol and opioid use disorders, but various studies have documented its involvement in cancer progression, exploring possible anticancer potential, when administered at high doses or as low dose naltrexone (LDN). Herein we present a systematic review of cancer-related outcomes from case reports, clinical trials, and retrospective and prospective studies conducted using cell cultures, animal models, and h...
Use of low-dose naltrexone in the management of chronic pain conditions: A systematic review.
Research Type Human Reported as Review Date December 01, 2020 Authors E. Hatfield, K. Phillips, S. Swidan S, L. Ashman Institution University of Michigan Disease Chronic Pain
BACKGROUND: The authors aimed to evaluate the efficacy of low-dose naltrexone in the management of chronic pain conditions and determine its potential use in orofacial pain management. METHODS: A comprehensive literature review was completed in the PubMed/MEDLINE, Embase, Cumulated Index to Nursing and Allied Health Literature, Dentistry and Oral Sciences Source Library databases up through June 17, 2019, using terms such as neurogenic, inflammation, naltrexone, temporomandibular, and chronic ...
Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone
Research Type Human Reported as Case Report/Series/Restrospective Study Date November 01, 2020 Authors Michael M, Benjamin MW, Shannon CT Institution Honor Health/Affiliated Dermatology; Larkin Community Hospital, Oakview Dermatology Disease Hailey-Hailey
Hailey-Hailey (HHD), or benign familial chronic pemphigus disease, is a rare autosomal dominant blistering disorder characterized by recurrent vesicles that erode and macerate into weeping and crusting plaques. HHD has been shown to be resistant to several treatment options. Although not yet approved as a treatment for HHD, recent reports have suggested the use of low-dose naltrexone (LDN) as a successful treatment option for controlling recalcitrant HHD. We present a case of a 50-year-old woman...
Perspectives on Low Dose Naltrexone Use in Treatment of Autoimmune Pathology and Endometriosis
Research Type Human Reported as Review Date November 01, 2020 Authors O. V. Golianovskyi, O. O. Andrienko, O. V. Furman, Phil Boyle Institution Shupyk National Medical Academy of Postgraduate Education, Vinnytsia National Pirogov Memorial Medical University; International Institute for Restorative Reproductive Medicine Disease Endometriosis
There are still many complex issues in the management of autoimmune pathologies in gynecology and reproductology, endometriosis in particular. Naltrexone, a competitive antagonist of opiate receptors in the central and peripheral nervous systems, reveals new qualities such as effects on autoimmune processes. Naltrexone in low doses of 1.7–5 mg (Low Dose Naltrexone, LDN) revealed the opposite effect on opiate receptors in the form of a rebound effect and, as a consequence, a strong increase in ...

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