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Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review
Research Type Human Reported as Review Date August 26, 2020 Authors Phillip S Kim, Michael A Fishman Institution Center for Interventional Pain & Spine Disease Chronic Pain
PURPOSE OF REVIEW: The purpose of this review is to evaluate and explain our current understanding of the clinical use of low-dose naltrexone in the treatment of chronic pain. RECENT FINDINGS: Recent pre-clinical uses and clinical studies further elucidate the use of low-dose naltrexone in the treatment of chronic pain. Low-dose naltrexone (LDN) has shown promise to reduce symptoms related to chronic pain conditions such as fibromyalgia, inflammatory bowel conditions, and multiple sclerosis. The...
Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review.
Research Type Human Reported as Case Report/Series/Restrospective Study Date August 10, 2020 Authors M. Sousa Gomes, J .Araújo Pereira, V. Trocado, JP Prata, V. Teixeira, P. Pinheiro Institution University of Minho; Hospital Particular Viana do Castelo Disease Hailey-Hailey
PURPOSE: To report a case of vulvar familial benign pemphigus, or Hailey-Hailey disease, treated successfully with low-dose naltrexone and to review the current literature. METHODS: We report a case of a 71-year-old white woman with vulvar Hailey-Hailey disease recalcitrant to topical corticosteroids. After treatment with low-dose naltrexone, 3 mg nightly was initiated, the lesions began to heal and 5 months later her skin showed no lesions. A literature review on the use of low-dose naltrexon...
Sjogren's Syndrome and Clinical Benefits of Low-Dose Naltrexone Therapy: Additional Case Reports
Research Type Human Reported as Case Report/Series/Restrospective Study Date July 01, 2020 Authors Scott Zashin Institution University of Texas Southwest Medical Center Disease Sjogren’s
Sjogren's syndrome (SS) is a chronic autoimmune disorder that causes the inflammation of the lacrimal and salivary glands, resulting in dryness of the eyes and mouth. In addition, fatigue and musculoskeletal pain, often described as aching, are very common. Treatment directed towards alleviating the fatigue and pain associated with SS is currently very limited. In March of 2019, the first peer reviewed case report showing clinical improvement using low-dose naltrexone (LDN) in a patient with sus...
Efficacy of Low Dose Naltrexone in Psoriasis
Research Type Human Reported as Clinical Trial Date June 30, 2020 Authors Sidra Khan, Rabia Ghafoor, Sana Kaleem Institution Jinnah Postgraduate Medical Centre Disease Psoriasis
OBJECTIVE: To determine the efficacy of low dose naltrexone in the patients of psoriasis. Study design: Non-randomised clinical trial. Place and duration of study: Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi from January to July 2019. METHODOLOGY: All patients of mild, moderate, and severe psoriasis with age above 13 years without any comorbids were included in this study. Patients were started on tablet naltrexone 6mg daily after assessing PASI, BSA and DLQI scores...
Efficacy and Tolerability of Low-dose Naltrexone for Pain Relief among Neuropathic Corneal Pain Patients
Research Type Human Reported as Case Report/Series/Restrospective Study Date June 15, 2020 Authors Gabriela Dieckmann; Mehmet Cuneyt Ozmen; Ryan Engert; Pedram Hamrah Institution Tufts Medical Center Disease Neuropathic Corneal Pain
PURPOSE: Neuropathic corneal pain (NCP) is a recently described ocular pain modality resulting from nerve damage and presenting with symptoms of pain or persistent unpleasant sensations, such as dryness, burning, or light sensitivity. When symptoms do not resolve with topical anesthetics, this point to a non-ocular source of pain. Low-dose naltrexone (LDN) acts as a neuromodulator with a neuroprotective effect via inhibition of microglial activation in the central nervous system and upregulation...
Hailey-Hailey Disease Successfully Treated with Low-Dose Naltrexone
Research Type Human Reported as Case Report/Series/Restrospective Study Date May 31, 2020 Authors John Moesch, Richard Miller Institution Largo Medical Center Disease Hailey-Hailey
Hailey-Hailey disease (HHD) is an uncommon autosomal dominant disorder resulting from a mutation in the ATP2C1 gene resulting in dysfunction of the Golgi apparatus calcium-associated ATPase, thus interfering with intercellular calcium signaling. HHD presents clinically as flaccid blisters and erosions in intertriginous areas, especially the axillae and groin. The major histologic finding is acantholysis throughout the spinous layer of the epidermis, commonly referred to as a “dilapidated bric...
The efficacy and safety of oral low dose naltrexone versus placebo in the patients with lichen planopilaris; a randomized controlled clinical trial.
Research Type Human Reported as Clinical Trial Date May 23, 2020 Authors Vahideh Lajevardi, Fereshteh Salarvand, Maryam Ghiasi,Maryam Nasimi, Mohammad Taraz Institution Tehran University of Medical Sciences Disease Lichen Planopilaris
BACKGROUND: Lichen planopilaris (LPP) is one of the important causes of cicatricial alopecia. We aimed to evaluate the efficacy and safety of low-dose naltrexone (LDN) in the setting of a clinical trial in patients with LPP. METHODS: We included patients with LPP between 2018 and 2020. Patients were allocated to two groups. The first group received topical clobetasol plus oral low dose naltrexone (3mg) while the second received topical clobetasol plus placebo. The assessment was made for the d...
Erythromelalgia in a Patient with Mast Cell Activation Syndrome: Response to Low Dose Naltrexone
Research Type Human Reported as Case Report/Series/Restrospective Study Date May 13, 2020 Authors Anastasia O Kurta, Leonard B Weinstock, Natalie Semchyshyn Institution Saint Louis University, Specialists in Gastroenterology Disease Erythromelalgia, MCAS (mast cell activation syndrome)
Erythromelalgia is a rare condition that may be associated with a variety of underlying conditions and is often refractory to therapy. We report a case of a patient with mast cell activation syndrome who developed erythromelalgia and responded to low dose naltrexone....
Low-dose Naltrexone Therapy for Psoriasis
Research Type Human Reported as Case Report/Series/Restrospective Study Date March 21, 2020 Authors L. B. Weinstock, J. Cottel, L. Aldridge, A. Egeberg Institution Washington University School of Medicine, University of Copenhagen Disease Psoriasis
Safe, inexpensive, and convenient psoriasis therapy is desirable. Two recent case reports suggested that low-dose naltrexone is effective. Cases from our practice are presented in order to further the evidence of efficacy and safety of low-dose naltrexone in the treatment of psoriasis. Patients included 13 females, 2 males; mean age 57 years; mean psoriasis duration 16 years. Of the patients, 8 had psoriatic arthritis. In the past, 5 had completely failed and 10 had partially responded t...
Naltrexone Hydrochloride 1.5-mg and 4.5-mg Capsules
Research Type Human Reported as Review Date March 19, 2020 Authors Loyd V. Allen, Jr., PhD Institution University of Oklahoma
Pharmacist Dr. Loyd V. Allen, Jr. reviews methods of preparation, uses, packaging, labeling, stability, and quality control of 1.5mg and 4.5mg capsules of low dose naltrexone. An interesting and unexpected effect of naltrexone is its action in pain relief for different disorders. A notable aspect of naltrexone use in pain patients is that the dose is only about one-tenth of the normal dose. Since naltrexone HCl is available in 50-mg tablets, low-dose naltrexone must be compounded for patients....

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