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Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology in female mice with experimental autoimmune encephalomyelitis.
Research Type Animal Date November 25, 2021 Authors C. Patel, IS Zagon, M. Pearce-Clawson, PJ McLaughlin PJ Institution Pennsylvania State University College of Medicine Disease MS (Multiple Sclerosis)
Multiple sclerosis (MS) is a progressive disease of the central nervous system (CNS) that primarily affects women during the second or third decade of life. The mechanism is hypothesized to involve unregulated peripheral inflammation resulting in blood-brain barrier damage, and eventual axonal damage and demyelination. Based on this understanding, the animal model of MS, experimental autoimmune encephalomyelitis (EAE), often is utilized to study lymphocyte activation. Therapeutic paradigms of ex...
Prurigo excoriée treated with low dose naltrexone
Research Type Human Reported as Case Report/Series/Restrospective Study Date November 19, 2021 Authors Leonard Timoney, Christopher B Bunker Institution University College London Hospitals NHS Foundation Trust Disease Pruritus
A 53-year-old woman presented with a 25-year history of acne excoriée and prurigo excoriée. Her symptoms began in 1988 coinciding with her husband's death from a brain tumour when she was 27. The pruritus affected her quality of life and disturbed her sleep. She had scarring on her face and body resulting from persistent scratching. The pruritus proved refractory to treatment despite a multi-modal treatment approach including multiple topicals, phototherapy and systemic agents such as isotreti...
Therapeutic potential of long-acting opioids and opioid antagonists for SARS CoV-2 infection
Research Type Human Reported as Review Date September 15, 2021 Authors Marie Eagleton, Siobhan Stokes, Fiona Fenton, Eamon Keenan Institution HSE National Drug Treatment Centre (Ireland); National Social Inclusion Office
Aware of few reports of COVID-19 in patients undergoing opioid substitution treatment, we proposed that OST may have a protective effect on clinical manifestations of COVID-19 based on a publication proposing an interaction between opioids and SARS-CoV-2 pathology. Consideration of possible mechanisms to explain a low incidence of disease in opioid substitution treatment patients raises the possibility that specific opioids interfere with the pathogenesis of SARS-CoV2, thereby affecting clinica...
Immunometabolic Modulatory Role of Naltrexone in BV-2 Microglia Cells
Research Type Human Lab (in-vitro) Date August 05, 2021 Authors N. Kučić, V. Rački, R. Šverko, T. Vidović T, I. Grahovac, J. Mršić-Pelčić J Institution University of Rijeka, Clinical Hospital Center Rijeka, Pharmacy Irena Grahovac
BACKGROUND: Naltrexone is an opioid receptor antagonist commonly used to treat opioid and alcohol dependence. The use of low dose naltrexone (LDN) was found to have anti-inflammatory properties for treatment of diseases such as fibromyalgia, Crohn's disease, multiple sclerosis and regional pain syndromes. Related to its anti-neuroinflammatory properties, the mechanism of action is possibly mediated via Toll-like receptor 4 antagonism, which is widely expressed on microglial cells. The aim of the...
LDN Protects Bone Property Deterioration at Different Hierarchical Levels in T2DM Mice Bone
Research Type Animal Date July 28, 2021 Authors P. Shitole, A. Choubey, P. Mondal, R. Ghosh Institution Indian Institute of Technology at Mandi Disease Diabetes
Type 2 diabetes mellitus (T2DM) commonly affects bone quality at different hierarchical levels and leads to an increase in the risk of bone fracture. Earlier, some anti-diabetic drugs showed positive effects on bone mechanical properties. Recently, we have investigated that low-dose naltrexone (LDN), a TLR4 antagonist treatment, improves glucose tolerance in high-fat diet (HFD)-induced T2DM mice and also gives protection against HFD-induced weight gain. However, effects on bone are still unknown...
Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment
Research Type Human Reported as Case Report/Series/Restrospective Study Date July 13, 2021 Authors H. Cabanas, K. Muraki, N. Eaton-Fitch, D.R. Staines, S. Marshall-Gradisnik Institution Griffith University, Aichi-Gakuin University Disease CFS
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating multi-systemic chronic condition of unknown aetiology classified as an immune dysfunction syndrome and neurological disorder. The discovery of the widely expressed Transient Receptor Potential Melastatin 3 (TRPM3) as a nociceptor channel substantially targeted by certain opioid receptors, and its implication in calcium (Ca2+)-dependent Natural Killer (NK) cell immune functions has raised the possibility that TRPM3 may ...
Low Dose Naltrexone in Endometrial Intraepithelial Neoplasia
Research Type Human Reported as Case Report/Series/Restrospective Study Date July 07, 2021 Authors Anne Marie McKenzie-Brown, Namita Khanna, Vinita Singh Institution Emory University Disease Endometrial Intraepithelial Neoplasia
Case report of a 43 year old woman whose endometrial intraepithelial neoplasia (EIN) resolved following initiation of low dose naltrexone for pain management. EIN is a premalignant lesion of the uterine lining that predisposes one to uterine cancer....
Low-Dose Naltrexone Use for Patients with Complex Regional Pain Syndrome: A Systematic Literature Review
Research Type Human Reported as Review Date July 01, 2021 Authors A. Soin, Y. Soin, T. Dann, R. Buenaventura, K. Ferguson, S. Atluri, H. Sachdeva, G. Sudarshan, H. Akbik, J. Italiano Institution Wright State University; Ohio Pain Clinic; Pain Evaluation Management Center of Ohio; Pain Relief of Dayton; Aspirus Health Care of Wisconsin; Interventional Spine Specialists of Cincinnati; University of Cincinnati; Cincinnati Comprehensive Pain Center Disease Chronic Pain, CRPS
BACKGROUND: Complex regional pain syndrome is a rare, neuropathic disorder that affects fewer than 200,000 individuals in the United States annually. Current treatments often focus on pain management and fall short of relieving symptoms of pain and dystonia in patients. OBJECTIVE: The goal of this systematic qualitative review is to evaluate the evidence for the use of low-dose naltrexone in the treatment of chronic pain syndromes. STUDY DESIGN: This is a systematic review. METHODS: PubMed, E...
Low Dose Naltrexone in Conjunction With the Wahls Protocol to Reduce the Frequency of Chronic Migraines in a Patient With Multiple Sclerosis: A Case Study
Research Type Human Reported as Case Report/Series/Restrospective Study Date June 30, 2021 Authors H. Codino, A. Hardin Institution National University of Natural Medicine (NUNM) Health Centers Disease Migraine, MS (Multiple Sclerosis)
This case study investigates the efficacy of low dose naltrexone (LDN) and the Wahls Protocol in reducing the frequency and severity of chronic migraine headaches in a 62-year-old White female with multiple sclerosis. Migraines are common among the many debilitating symptoms of multiple sclerosis. A therapeutic intervention of low dose naltrexone titrated to 4.5 mg nightly in combination with dietary changes significantly improved the patient's quality of life by reducing the severity, duration,...
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System Involving Proopiomelanocortin Neurons and Beta-Endorphin.
Research Type Animal Lab (in-vitro) Date May 24, 2021 Authors MJ Metz, CM Daimon, ST Hentges Institution Colorado State University
Naltrexone is an opioid receptor antagonist approved for the treatment of alcohol and opioid use disorders at doses of 50-150 mg/d. Naltrexone has also been prescribed at much lower doses (3-6 mg/d) for the off-label treatment of inflammation and pain. Currently, a compelling mechanistic explanation for the reported efficacy of low-dose naltrexone (LDN) is lacking and none of the proposed mechanisms can explain patient reports of improved mood and sense of well-being. Here, we examined the p...

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