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Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment
Research Type Human Reported as Case Report/Series/Restrospective Study Date July 13, 2021 Authors H. Cabanas, K. Muraki, N. Eaton-Fitch, D.R. Staines, S. Marshall-Gradisnik Institution Griffith University, Aichi-Gakuin University Disease CFS
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating multi-systemic chronic condition of unknown aetiology classified as an immune dysfunction syndrome and neurological disorder. The discovery of the widely expressed Transient Receptor Potential Melastatin 3 (TRPM3) as a nociceptor channel substantially targeted by certain opioid receptors, and its implication in calcium (Ca2+)-dependent Natural Killer (NK) cell immune functions has raised the possibility that TRPM3 may ...
Low Dose Naltrexone in Endometrial Intraepithelial Neoplasia
Research Type Human Reported as Case Report/Series/Restrospective Study Date July 07, 2021 Authors Anne Marie McKenzie-Brown, Namita Khanna, Vinita Singh Institution Emory University Disease Endometrial Intraepithelial Neoplasia
Case report of a 43 year old woman whose endometrial intraepithelial neoplasia (EIN) resolved following initiation of low dose naltrexone for pain management. EIN is a premalignant lesion of the uterine lining that predisposes one to uterine cancer....
Low-Dose Naltrexone Use for Patients with Complex Regional Pain Syndrome: A Systematic Literature Review
Research Type Human Reported as Review Date July 01, 2021 Authors A. Soin, Y. Soin, T. Dann, R. Buenaventura, K. Ferguson, S. Atluri, H. Sachdeva, G. Sudarshan, H. Akbik, J. Italiano Institution Wright State University; Ohio Pain Clinic; Pain Evaluation Management Center of Ohio; Pain Relief of Dayton; Aspirus Health Care of Wisconsin; Interventional Spine Specialists of Cincinnati; University of Cincinnati; Cincinnati Comprehensive Pain Center Disease Chronic Pain, CRPS
BACKGROUND: Complex regional pain syndrome is a rare, neuropathic disorder that affects fewer than 200,000 individuals in the United States annually. Current treatments often focus on pain management and fall short of relieving symptoms of pain and dystonia in patients. OBJECTIVE: The goal of this systematic qualitative review is to evaluate the evidence for the use of low-dose naltrexone in the treatment of chronic pain syndromes. STUDY DESIGN: This is a systematic review. METHODS: PubMed, E...
Low Dose Naltrexone in Conjunction With the Wahls Protocol to Reduce the Frequency of Chronic Migraines in a Patient With Multiple Sclerosis: A Case Study
Research Type Human Reported as Case Report/Series/Restrospective Study Date June 30, 2021 Authors H. Codino, A. Hardin Institution National University of Natural Medicine (NUNM) Health Centers Disease Migraine, MS (Multiple Sclerosis)
This case study investigates the efficacy of low dose naltrexone (LDN) and the Wahls Protocol in reducing the frequency and severity of chronic migraine headaches in a 62-year-old White female with multiple sclerosis. Migraines are common among the many debilitating symptoms of multiple sclerosis. A therapeutic intervention of low dose naltrexone titrated to 4.5 mg nightly in combination with dietary changes significantly improved the patient's quality of life by reducing the severity, duration,...
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System Involving Proopiomelanocortin Neurons and Beta-Endorphin.
Research Type Animal Lab (in-vitro) Date May 24, 2021 Authors MJ Metz, CM Daimon, ST Hentges Institution Colorado State University
Naltrexone is an opioid receptor antagonist approved for the treatment of alcohol and opioid use disorders at doses of 50-150 mg/d. Naltrexone has also been prescribed at much lower doses (3-6 mg/d) for the off-label treatment of inflammation and pain. Currently, a compelling mechanistic explanation for the reported efficacy of low-dose naltrexone (LDN) is lacking and none of the proposed mechanisms can explain patient reports of improved mood and sense of well-being. Here, we examined the p...
Efficacy and safety of low-dose naltrexone in painful diabetic neuropathy: A randomized, double-blind, active-control, crossover clinical trial
Research Type Human Reported as Clinical Trial Date May 20, 2021 Authors Anand Srinivasan, Pinaki Dutta, Dipika Bansal, Amitava Chakrabarti, Anil Kumar Bhansali, Debasish Hota Institution All India Institute of Medical Sciences, Postgraduate Institute of Medical Education and Research, National Institute of Pharmaceutical Education and Research Disease Chronic Pain, Diabetic Neuropathy
BACKGROUND: There is a need for newer therapies for chronic painful diabetic neuropathy as the existing drugs have their own limitations. Clinical trials on low-dose naltrexone (1-5 mg/day) showed efficacy and safety in certain chronic painful conditions, but not in painful diabetic neuropathy. Hence the present study was planned. METHODS: Sixty-seven participants with painful diabetic neuropathy were randomized to receive either 2 mg naltrexone or 10 mg amitriptyline daily following a 2-week r...
Chromatin protein HMGB1 regulates hyperinsulinemia mediated insulin resistance: low-dose naltrexone rescues insulin resistance associated with hyperinsulinemia
Research Type Animal Date May 14, 2021 Authors Abhinav Choubey, Khyati Girdhar, Aditya K Kar, Shaivya Kushwaha, Manoj Kumar Yadav, Debabrata Ghosh, Prosenjit Mondal Institution Indian Institute of Technology- Mandi; Indian Institute of Toxicology Research; SRM University Disease Hyperinsulinemia
Insulin secretion with compensatory hyperinsulinemia where pancreatic β-cells are forced to secrete more insulin is central hallmark of peripheral insulin resistance and type 2 diabetes (T2DM). Considerable data have suggested that hyperinsulinemia itself leads to inflammation and Toll like Receptor-4 (TLR4) activation is critical determinant for this process. We found that hyperinsulinemia increases circulatory HMGB1 (an endogenous TLR4 ligand) by ensuring its nuclear-to-cytoplasmic shuttling ...
Management of Pediatric Complex Regional Pain Syndrome with Low-Dose Naltrexone
Research Type Human Reported as Case Report/Series/Restrospective Study Date May 01, 2021 Authors Amol Soin Institution Wright State University Disease CRPS
BACKGROUND: Complex regional pain syndrome (CRPS) is a chronic, orphan neurologic condition that affects the extremities after nerve trauma or injury. Management of CRPS can be challenging due to a paucity of evidence surrounding treatment options. Low-dose naltrexone (LDN) has been used for the management of other types of chronic pain. LDN is believed to exert its activities through inhibition of Toll-like receptor 4, which attenuates microglial activation. This case report describes the use o...
Utilization of Low-Dose Naltrexone for Burning Mouth Syndrome: A Case Report
Research Type Human Reported as Case Report/Series/Restrospective Study Date April 19, 2021 Authors Daniel Neuman, Andrea Chadwick, Andrea Institution University of Kansas Medical Center Disease Burning Mouth Syndrome
Burning mouth syndrome is a chronic pain condition characterized by a burning sensation of the oropharynx. The pathophysiology of burning mouth syndrome includes peripheral and central sensitization. Treatment is generally aimed at symptom reduction. We describe a woman in her seventh decade with burning mouth syndrome that had been refractory to treatment for nearly a decade. Low-dose naltrexone has been reported to provide analgesia in central sensitization states and was successful in reducin...
A Review of the Integrative Treatment Approach Using the Intravenous Alpha-Lipoic Acid/Low Dose Naltrexone (ALA/N) Protocol for Cancer and a Description of the Long-Term Survival of a Woman with Hepatocellular Carcinoma
Research Type Human Reported as Case Report/Series/Restrospective Study Date March 16, 2021 Authors Burton M Berkson, Francisco Calvo Riera Institution The Integrative Medical Center of New Mexico; Spain Autoimmune and Chronic Diseases Clinic Disease Cancer (general), Hepatocellular Carcinoma , Liver Cancer
In this paper we describe the treatment of a 71-year-old female registered nurse (JA) diagnosed with Hepatocellular Carcinoma (HCC) in early October 2006. The patient was a heavy smoker and drank alcohol on weekends. She contracted hepatitis C following a finger sticks from a patient with the disease. Several years later she developed HCC. Her doctor at a large medical center, after viewing her CT scans, told her that with so many tumors in her liver, only a liver transplant would offer some hop...

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