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Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study
Research Type Human Reported as Clinical Trial Date August 01, 2022 Authors Brendan O'Kelly, Louise Vidal, Tina McHugh, James Woo, Gordana Avramovic, John S.Lambert Institution Mater Misericordiae University Hospital, University College Dublin Disease Covid-19
BACKGROUND: Up to 37.7% of patients experience symptoms beyond 12 weeks after infection with SARS-CoV-2. To date care for people with long covid has centred around multidisciplinary rehabilitation, self care and self pacing. No pharmacotherapy has been shown to be beneficial. METHODS: In this single centre interventional pre post study, the safety of Low Dose Naltrexone (LDN) was explored in patients with Post COVID-19 Syndrome (PCS), defined by NICE as patients with ongoing symptoms 12 or more...
Recalcitrant cases of Hailey-Hailey disease successfully managed with low-dose naltrexone
Research Type Human Reported as Case Report/Series/Restrospective Study Date July 02, 2022 Authors HR Vyas, SR Shah, HS Patel, BJ Shah Institution B.J. Medical College and Civil Hospital Disease Hailey-Hailey
Recalcitrant cases of Hailey-Hailey disease successfully managed with low-dose naltrexone...
The role of immune modulation and anti-inflammatory agents in the management of prostate cancer: A case report of six patients.
Research Type Human Reported as Case Report/Series/Restrospective Study Date June 07, 2022 Authors AG Dalgleish, WM Liu Institution St. George's University of London Disease Cancer (general), Prostate Cancer
Cancer is associated with chronic inflammation and disruption to normal immune function. As such, the ability to thrive in a chronically inflamed microenvironment is regarded as a hallmark of cancer. Therefore, targeting inflammation and/or correction of aberrant immunity has been a therapeutic aim. The aim of the present study was to describe the use of a novel immunotherapy, called IMM-101, which is a naturally occurring, heat-killed whole cell mycobacterium, used in combination with conventio...
Reversible Hair Loss in Lichen Planopilaris: Regrowth With Low-Dose Naltrexone and Platelet-Rich Plasma
Research Type Human Reported as Case Report/Series/Restrospective Study Date June 01, 2022 Authors E Klein, M Karim, R Kim, K Lo Sicco, J Shapiro Institution NYU Grossman School of Medicine; Hackensack Meridian School of Medicine Disease Lichen Planopilaris
Lichen planopilaris (LPP) is a cicatricial alopecia that presents with patchy or diffuse hair loss at the vertex or parietal scalp. The literature has limited evidence on treatments for this challenging disease, with most reports involving small groups of patients with varied or suboptimal clinical responses. Amongst individuals who do respond to therapy and eventually achieve disease remission, hair regrowth within scarred alopecic patches is rare.1 Herein, we report a patient with biopsy confi...
Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction?
Research Type Lab (in-vitro) Reported as Review Date June 01, 2022 Authors A Belltall, G Mazzinari, O Diaz-Cambronero, P Eroles, MP Argente Navarro Institution Hospital Universitario y Politécnico la Fe; Euro-Periscope, Onco-Anaesthesiology Research Group (RG) of European Society of Anaesthesiology and Intensive Care; INCLIVA Biomedical Research Institute; University of Valencia INCLIVA-Hospital Clínico de Valen Disease Cancer (general)
Antagonists of mu-opioid receptor role in cancer progression remains to be elucidated. The objective of this review was to summarize the available evidence on antagonists of mu-opioid receptor effect on tumor progression and prognosis in different types of cancers and an evaluation of the available findings on their mechanism of action. We have found studies related to methylnaltrexone (MNTX) and naltrexone (NTX) usage in cancer outcomes-related setting. We found consistent preclinical evidence ...
Low-dose naltrexone for treatment of burning mouth syndrome
Research Type Human Reported as Case Report/Series/Restrospective Study Date April 30, 2022 Authors L Sangalli, CS Miller Institution University of Kentucky Disease Burning Mouth Syndrome
OBJECTIVE: The International Classification of Disease defines burning mouth syndrome (BMS) as a chronic intraoral burning sensation, with no identifiable local or systemic cause. Since current management is often unsatisfactory, the aim of this report is to describe a new treatment modality (i.e., low-dose naltrexone [LDN]). STUDY DESIGN: A 62-year-old woman presented with the complaint of burning on the tongue of 3 years' duration. Existing comorbidities were fibromyalgia, irritable bowel synd...
Use of Off-Label Drugs and Nutrition Supplements among Patients with Amyotrophic Lateral Sclerosis in Norway
Research Type Human Reported as Clinical Trial Date April 12, 2022 Authors GA Skulstad Johanson, OB Tysnes, TL Bjerknes Institution University of Bergen; Haukeland University Hospital Disease Amyotrophic Lateral Sclerosis (ALS)
A cross-sectional questionnaire study was performed, where 41 ALS patients reported their use of off-label treatments, as well as self-perceived HRQOL using the RAND-12 questionnaire. A majority of respondents used riluzole. Of the 41 respondents, 18 (43.9%) reported use of off-label medications and 18 (43.9%) used nutritional supplements. Low-dose naltrexone was the most commonly used off-label medication, whereas vitamins accounted for most of the nutritional supplements. The respondents' RAN...
The State-of-the-art Pharmacotherapeutic Options for the Treatment of Chronic Non-Cancer Pain
Research Type Human Reported as Review Date March 31, 2022 Authors RS D'Souza, B Langford B, RE Wilson, YF Her, J Schappell, JS Eller, TC Evans, JM Hagedorn Institution Mayo Clinic Hospital; Spine Pain Physicians Disease Chronic Pain
Pharmacotherapeutic options continue to expand for the treatment of chronic non-cancer pain. There has been an increasing emphasis on multimodal analgesia. This strategy employs use of multiple analgesic medications each with a distinct mechanism of action, which when administered concomitantly may provide profound analgesia. The authors describe evidence from randomized controlled trials and systematic reviews on a variety of established medications including anti-inflammatory agents, opioids, ...
Low-dose naltrexone, an opioid-receptor antagonist, is a broad-spectrum analgesic: a retrospective cohort study
Research Type Human Reported as Case Report/Series/Restrospective Study Date March 15, 2022 Authors Samuel J Martin, Heath B McAnally, Paul Okediji, Moshe Rogosnitzky Institution MedInsight Research Institute, University of Washington School of Medicine, Loma Linda University School of Medicine, Northern Anesthesia & Pain Medicine Disease Chronic Pain
Naltrexone has historically been used to treat various substance use disorders, but recent discoveries have sparked interest in using low-dose naltrexone (LDN) to manage chronic pain. This study compared pain levels reported by patients before and after at least 2 months of LDN treatment to those reported by patients with the same painful diseases, who did not take LDN. Overall, patients who took LDN reported significantly more pain relief than patients who did not take LDN. How LDN alleviates p...
Depression in Fibromyalgia Patients May Require Low-Dose Naltrexone to Respond: A Case Report
Research Type Human Reported as Case Report/Series/Restrospective Study Date February 28, 2022 Authors Jagoda Siembida, Brian Johnson Institution SUNY Upstate Medical University Disease Depression, Fibromyalgia
Fibromyalgia and depression are frequently comorbid. We propose a hormonal system model in understanding the underlying endogenous opioid system dysregulation in fibromyalgia with the utilization of the cold pressor test (CPT) in clinical practice to monitor treatment response to low-dose naltrexone (LDN) and the subsequent remission of major depressive disorder by restoring opioid tone. A 60-year-old professional on permanent disability presented with refractory depression and chronic widespre...

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