Find us on:


Research Type
Reported as
Publication Type
Sort By
Total: 198
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with Neuropathic Corneal Pain
Research Type Human Reported as Case Report/Series/Restrospective Study Date January 12, 2021 Authors G. Dieckmann, MC Ozmen, SM Cox, RC Engert, P. Hamrah Institution Tufts University School of Medicine Disease Neuropathic Corneal Pain
PURPOSE: Neuropathic corneal pain (NCP) is caused, by damage or disease of the somatosensory nervous system that innervates the cornea and presents with symptoms of pain or persistent unpleasant sensations, such as burning, dryness, or light sensitivity. This retrospective study aims to assess the efficacy and tolerability of low-dose naltrexone (LDN) in refractory NCP patients. METHODS: Fifty-nine NCP patients with a centralized component treated with oral LDN 4.5  mg at bedtime for at ...
Improvement in Hailey–Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report
Research Type Human Reported as Case Report/Series/Restrospective Study Date December 25, 2020 Authors Darosa Lim, Annie Belisle, Sandra Davar Institution Centre Hospitalier de l’Université de Montréal Disease Hailey-Hailey
Hailey–Hailey disease is a rare autosomal dominant acantholytic disorder due to mutation in the ATP2C1 gene and presents with flaccid blisters in intertriginous regions. Its chronic and relapsing course may negatively impact patients’ quality of life. Multiple medical and interventional treatments have been described with various efficacy. Low-dose naltrexone and oral magnesium chloride represent emerging treatments. Sustained improvement in Hailey–Hailey disease has been reported with the...
Naltrexone's Impact on Cancer Progression and Mortality: A Systematic Review of Studies in Humans, Animal Models, and Cell Cultures
Research Type Human Animal Lab (in-vitro) Reported as Review Date December 18, 2020 Authors Karina Liubchenko, Kevin Kordbacheh, Nika Khajehdehi, Tanja Visnjevac, Frederick Ma, James S. Khan, Myles Storey, Alaa Abd-Elsayed & Ognjen Visnjevac Institution Western University Schulich School of Medicine; 2Bloor Pain Specialists, University of Toronto Mount Sinai Hospital, University of Wisconsin-Madison, McMaster University Disease Cancer (general)
BACKGROUND: Naltrexone (NTX) is an opioid antagonist traditionally used as a treatment for alcohol and opioid use disorders, but various studies have documented its involvement in cancer progression, exploring possible anticancer potential, when administered at high doses or as low dose naltrexone (LDN). Herein we present a systematic review of cancer-related outcomes from case reports, clinical trials, and retrospective and prospective studies conducted using cell cultures, animal models, and h...
Use of low-dose naltrexone in the management of chronic pain conditions: A systematic review.
Research Type Human Reported as Review Date December 01, 2020 Authors E. Hatfield, K. Phillips, S. Swidan S, L. Ashman Institution University of Michigan Disease Chronic Pain
BACKGROUND: The authors aimed to evaluate the efficacy of low-dose naltrexone in the management of chronic pain conditions and determine its potential use in orofacial pain management. METHODS: A comprehensive literature review was completed in the PubMed/MEDLINE, Embase, Cumulated Index to Nursing and Allied Health Literature, Dentistry and Oral Sciences Source Library databases up through June 17, 2019, using terms such as neurogenic, inflammation, naltrexone, temporomandibular, and chronic ...
Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone
Research Type Human Reported as Case Report/Series/Restrospective Study Date November 01, 2020 Authors Michael M, Benjamin MW, Shannon CT Institution Honor Health/Affiliated Dermatology; Larkin Community Hospital, Oakview Dermatology Disease Hailey-Hailey
Hailey-Hailey (HHD), or benign familial chronic pemphigus disease, is a rare autosomal dominant blistering disorder characterized by recurrent vesicles that erode and macerate into weeping and crusting plaques. HHD has been shown to be resistant to several treatment options. Although not yet approved as a treatment for HHD, recent reports have suggested the use of low-dose naltrexone (LDN) as a successful treatment option for controlling recalcitrant HHD. We present a case of a 50-year-old woman...
[Met 5]-enkephalin preserves diffusion metrics in EAE mice
Research Type Animal Date October 01, 2020 Authors Chirag Patel, Mark D Meadowcroft, Ian S Zagon, Patricia J McLaughlin Institution Pennsylvania State University Disease MS (Multiple Sclerosis)
Multiple sclerosis is a chronic progressive neurological disorder that has few distinctive biomarkers associated with disease progression or response to therapy. This research investigated whether non-invasive imaging correlated with animal behavior and morphological indicators of disease in response to serum levels of [Met5]-enkephalin. Using the experimental autoimmune encephalomyelitis (EAE) model, adult female C57BL/6 J mice were randomized to receive daily injections of 0.1 mg/kg naltrexone...
No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study.
Research Type Human Reported as Case Report/Series/Restrospective Study Date October 01, 2020 Authors Guttorm Raknes, Lars Småbrekke Institution University Hospital of North Norway, Raknes Research, The Arctic University of Norway at Tromsø. Disease Hypothyroidism
BACKGROUND: Low dose naltrexone (LDN) is reported to have beneficial effects in several autoimmune diseases. The purpose of this study was to examine whether starting LDN was followed by changes in the dispensing of thyroid hormones to patients with hypothyroidism. METHODS: We performed a quasi-experimental before-after study based on the Norwegian Prescription Database. Study participants were identified by using reimbursement codes for hypothyroidism. Cumulative dispensed Defined Daily Doses...
Low dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia
Research Type Animal Reported as Clinical Trial Date September 17, 2020 Authors Abhinav Choubey, Khyati Girdhar, Aditya K Kar, Shaivya Kushwaha, Manoj Kumar Yadav, Debabrata Ghosh, Prosenjit Mondal Institution Indian Institute of Technology, Mandi; Council of Scientific and Industrial Research- Indian Institute of Toxicology Research; SRM University; Disease Hyperinsulinemia
The incidence of diabetes, obesity, and metabolic diseases has reached an epidemic status worldwide. Insulin resistance is a common link in the development of these conditions, and hyperinsulinemia is a central hallmark of peripheral insulin resistance. However, how hyperinsulinemia leads to systemic insulin resistance is less clear. We now provide evidence that hyperinsulinemia promotes the release of soluble pro-inflammatory mediators from macrophages that lead to systemic insulin resistance. ...
Naltrexone a potential therapeutic candidate for COVID-19
Research Type Lab (in-vitro) Date September 15, 2020 Authors A. Choubey, B. Dehury, S. Kumar, B. Medhi, P. Mondal Institution Indian Institute of Technology Mandi, Kalinga Institute of Industrial Technology, ICAR-Indian Agricultural Statistical Research Institute, Chandigarh Post Graduate Institute of Medical Education and Research Disease Covid-19
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Coronavirus Disease (COVID-19) that has resulted in a global pandemic. At the time of writing, approximately 16.06 million cases have been reported worldwide. Like other coronaviruses, SARS-CoV-2 relies on the surface Spike glycoprotein to access the host cells, mainly through the interaction of its Receptor Binding Domain (RBD) with the host receptor Angiotensin-Converting Enzyme2 (ACE2). SARS-CoV-2 infection induces a...
Dual Opioid Systems: A Simpler Explanation for Naltrexone Efficacy in Fibromyalgia
Research Type Human Reported as Opinion Date September 12, 2020 Authors Mark A Gillman, DSc Institution South African Brain Research Institute, Johannesburg, South Africa Disease Fibromyalgia
Letter to the editor regarding a suggestion for an alterative explanation for the paradoxical beneficial effect of LDN described in the previously published article, “Low-Dose Naltrexone for the Treatment of Fibromyalgia: Investigation of Dose–Response Relationships.”...

male enhancement: blue heart pill penile nerve damage symptoms ways to get erect fast complete multivitamins how to increase erection sildenafil 50 mg online penis enlargement system viagra actress man tea rock hard formula reviews surgery to make penis longer penis enlargement spell weider prime testosterone reviews viagra otc usa testicular health supplement biaxin allergy potency man how long do the effects of levitra last male enhancement uk buy medicene penile injections cost nitric oxide erection male enhancement tools warts are caused by quizlet make penis smaller why morning erection best nitric oxide foods try sexual herbal cure for ed long jack supplement kegel exercise for erectile dysfunction anabolic testosterone booster erectile dysfunction pills walgreens magnesium citrate vitamin shoppe viagra price costco male enhancement las vegas girl takes viagra

weight loss: meghan trainor weight loss best cheap weight loss pills for women best weight loss plan 2016 green tea capsules for weight loss vyvanse weight loss stories bygone brand of weight loss pills ginger root for weight loss best weight loss diet for seniors weight loss device rocks diet pills cheap weight loss diet plan white rice weight loss prednisone and weight loss cleanse for quick weight loss scale for weight loss weight loss tulsa bodybuilding weight loss supplements lemon and honey weight loss top 10 foods for weight loss best weight loss workouts yellow weight loss pills blac chyna kellie copeland swisher weight loss lipofuze weight loss pills does weight loss lower blood pressure thrive diet pills estrogen dominance weight loss mango diet pills weekly diet plan weight loss trufix diet pills reviews fat burning diet pills menopause diet weight loss plan easy weight loss breakfast diet for weight loss with pcos trampoline weight loss running diet for weight loss sacred heart diet weight loss

cbd oil: what are the side effects of cbd hemp cbd oil drops under tongue today show cbd oil how much thc will get you high best cbd oil for ibs best rated cbd oils cbd store greece ny canalux cbd oil thrive cbd vape cartridge full spectrum cbd oil price bulk thc solubility chart where can you purchase cbd oil cbd rsho blue 21 med pure cannabinol isolate is cbd oil illegal in nebraska treasure valley cbd difference between cbd isolate and cbd distillate oil products cannabis drug interactions cbd oil for cats diabetes gummy drop unlimited lives e juice recipe clones chagas disease map smok alien 220w wont turn on no effect from cbd oil cbd packaging cbd oil for sale in ct what is the difference between cbd tincture and cbd oil ensohara full spectrum cbd oil creating better days cbd gummies cbd oil 100mg per 4oz medicine leaflet cbd oil for bells palsy massage melbourne cbd full body does cbd oil help with canine osteosarcoma can cbd oil make you dizzy

vape: smooth vape vapor all viking vape vapor tricks 4 battery vape uwell crown tips hush vape pen vape store san jose 1937 vape cartridge oklahoma ecig explosion meme eco vape long beach uwell crown tank rba base vape wilmington nc 300mg cbd vape pen wotofo vape vape pen refill flavors king cake vape wild value vapor killer kustard vape juice jetty cartridges e cigarette maxx love vape shop ice stick vape e cigarette filters how many hits in a juul pod vapor pens starter kit eroll vape voopoo drag v2 cant open battery door uwell nunchaku mod with uwell crown 3 tank farm to vape amazon uwell crown 3 tank pyrex replaceent glass vapor depot usa unlock my voopoo 0 mg vape juice voopoo drag nano vape charlottes web vape pen