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Combination of Metabolic Treatment of Aggressive Primary Brain Tumour and Multiple Metastases of the Brain

Title
Combination of Metabolic Treatment of Aggressive Primary Brain Tumour and Multiple Metastases of the Brain
Publication Type
Journal Article
Research Type
Human
Reported as
Clinical Trial
Date
July 05, 2016
Authors
Schwartz, L
Institution
Ecole Polytechnique
Link
Abstract

BACKGROUND: The combination of hydroxycitrate and lipoic acid has been demonstrated by several laboratories to be effective in reducing murine cancer growth. In previous article in 2014, we reported the fate of 11 patients treated for metastatic cancer unresponsive to chemotherapy. As of today, 32months after inclusion, five of these patients (45%) are still alive.

PATIENTS AND METHODS: We report the cases of 12 patients with advanced brain tumor. They were all treated with conventional treatment and a combination of sodium R lipoate (800 mgbid), hydroxycitrate at 500 mg tidand low-dose naltrexone at 5 mg at bedtime. Eight patients had primary brain tumour (n=8 including five glioblastomas) four patients had multiple brain metastases.

RESULTS AND DISCUSSION: The combination of conventional and metabolic treatment was well tolerated. Four out of five patients with gliobastoma are still alive and well. The longest follow-up is 7 years.The four patients with disease widely metastatic to the brain have experienced long-term survival. A randomized clinical trial of metabolic treatment associated with conventional treatment is warranted