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Effect of Low-Dose Naltrexone on Egyptian Children with Intractable Epilepsy: A Case Series Study

Title
Effect of Low-Dose Naltrexone on Egyptian Children with Intractable Epilepsy: A Case Series Study
Publication Type
Journal Article
Research Type
Human
Reported as
Case Report/Series/Restrospective Study
Date
December 23, 2021
Authors
Noha T Abokrysha, Nirmeen A Kishk, Amani M Nawito, Nesma Mounir
Institution
Cairo University
Link
Abstract

Epilepsy is a chronic neurological disorder affecting 50 million patients worldwide, in need of continuous treatment, while 30% of them are refractory to treatment. Despite multiple antiepileptic drugs are available for the treatment of epilepsy, still refractory epilepsy especially in children represents a social burden in developing countries. Low-dose naltrexone (LDN) has been proposed as an immune modulator in multiple diseases and proved benefit especially in diseases with immune dysregulation. The purpose of this study was to demonstrate the effect of LDN in the treatment of children with intractable epilepsy and discuss its potential role in epileptogenesis process. Our study noticed a marked improvement in children with intractable epilepsy after adding LDN on both the clinical and electrophysiological basis. This finding could open the window to a possible way of medical treatment in cases with intractable epilepsy.

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