Find us on:

Research

Immunological changes in IBD patients responding to low-dose naltrexone treatment

Title
Immunological changes in IBD patients responding to low-dose naltrexone treatment
Publication Type
Abstract/Poster/Letter
Research Type
Human
Reported as
Clinical Trial
Date
February 01, 2012
Authors
de Haar C, van der Ent C, Peppelenbosch MP, van der Woude CJ
Institution
Erasmus Medical Center
Link
Abstract

LDN has been shown to improve clinical disease scores and induce mucosal healing in a subset of Crohn's disease patients. Activation of the opioid growth factor - opioid growth factor receptor pathway is suggested to be the mechanism of action. Since this pathway could affect the activity of a variety of leukocytes, we investigated whether LDN treatment affects various immune parameters in IBD patients.

METHODS: Twenty IBD patients not responding to regular medication were treated with LDN (5mg/daily). Peripheral blood was collected before start of treeatment, and after 3 months and 6 months of treatment. Various leucocyte subsets were quantified using flow cytometry.

RESULTS: Of the 20 IBD patients treatment with LDN, 8 (40%) showed clinical response and all are in clinical remission. When comparing responders to non-responders with regard to the changes in leucocyte subsets, there was a striking increase in the CD16+ CD62-L+ CD14- monocyte population in patients responding to LDN therapy. This same population decreased in some of the patients no tresponding to LDN therapy.

CONCLUSIONS: LDN treatment was successful in part of the IBD patients not responding to other medication. Whether the CD16+ CD62-L+ CD14- moncyte population is a direct target of the opiod growth factor - opioid growth factor receptor signaling and therefore directly affected by the LDN treatment needs to be determined.

cbd oil: side effects of cbd oil tilray cbd emu oil cbd cannabis oil company new leaf naturals cbd oil ananda professional cbd oil reviews can you advertise cbd on facebook where to get cbd oil in kokomo in cbd oil idaho falls how much thc is in full spectrum cbd oil will you fail a drug test for cbd cbd oil golden co canna hemp psychosis after seizure hemp bombs cbd e liquid review cbd and zoloft california cbd companies cbd oil skin rash og kush cbd vape pure cbd hemp oil 550 epidiolex dosage marijuana cream for joint pain bill checker pen try the cbd reviews sniders discount pharmacy cbd market projections what does tetrahydrocannabinol mean australian unity dental melbourne cbd

weight loss: roseanne barr weight loss zach galifianakis 2015 weight loss paleo for weight loss sprint workouts for weight loss lean meats for weight loss cinnamon help in weight loss best detox tea for weight loss reviews vegan weight loss transformation do weight loss supplements work nude weight loss pics personalized weight loss planner crystal breeze weight loss dr oz fastest weight loss trintellix weight gain or loss herbalife weight loss programs jennifer hudson weight loss tmz what to take for weight loss doctor oz weight loss pills best effective weight loss pills whole 30 weight loss holly robinson peete diet pills abilify weight loss reviews quick weight loss kendall weight loss peptide military diet no weight loss khloe kardashian weight loss diet keto pills kelly clarkson dash diet plan for weight loss

male enhancement: percocet sexual side effects testofuel reviews bodybuilding flomax vs rapaflo viagra over the counter usa average viagra dose extra large penis pump ed pills walmart virectin pills is my penis big enough my cock pictures how to get hard for sex extenze safe micro penia penis types where can i purchase viagra ed sample pack culture care login natural t whats the average pennis size penis erection problems vita red supplement usa average penis size status blue star review sex really hard size genetics pills ageless mens health male extra enhancement pills do taller people have bigger penises

vape: brass vape mod smok nord 22 smart cart vape battery sauz vape cloud competition builds check atomizer uwell crown vapor smoking dangers vortex vapor custom ecig mod uwell crown and snow wolf volcano ecig near me voopoo drag 2te best ecig mod kit top e liquid flavors how to calculator ready to vape juice what is vape mod e cigarette png largest uwell tank e cigarette liquid 12mg custom vape wraps kamry k1000 epipe retro pipe e cigarette kit smok alien kit 220w tc mi pod pods aspire cf vape ugly butter why vape cbd smok osub 80w manual smok infinix pod life