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Low Dose Naltrexone as a Treatment for Chronic Pain

Low Dose Naltrexone as a Treatment for Chronic Pain
Publication Type
Research Type
Reported as
Case Report/Series/Restrospective Study
April 19, 2018
Jonathan Church, Matthew Jaycox
Rush University

The patient is a 53 year old female with past medical history of fibromyalgia and Ehlers-Danlos syndrome (EDS) who presented with severe chronic pain in her shoulders, wrists, and back. She also reported chronic fatigue, depression, and sleep disturbance. She was housebound and unable to work due to pain. She attempted multiple therapies without success including: SNRIs, TCAs, Calcium channel modulators. She was also taking tramadol, hydrocodone/acetaminophen, and diclofenac. Decision was made to start patient on low dose naltrexone, an off label therapy for treatment of chronic pain. LDN was started at 3 mg daily after cessation of opioids for 4 days. She was subsequently titrated up to 4.5 mg daily after showing no adverse drug effects or withdrawal symptoms. By her 6 weeks follow up, her pain was greater than 75% better. By 3 months, she reported “feeling 18 again” with no pain and was able to return work and perform all activities of daily living. Additionally, she reported improvement in depression, sleep disturbance, and fatigue.