Find us on:

Research

Low-Dose Naltrexone in newly diagnosed high-grade glioma: placebo-controlled, double-blind, randomized pilot study

Title
Low-Dose Naltrexone in newly diagnosed high-grade glioma: placebo-controlled, double-blind, randomized pilot study
Publication Type
Abstract/Poster/Letter
Research Type
Human
Reported as
Clinical Trial
Date
November 19, 2015
Authors
K. Peters, M. Affronti, S. Woodring, E. Lipp, P. Healy, F. McSherry, J. Herndon, II, C. Flahiff, E. Miller, M. Freeman, J. Minchew, B. Zalutsky, B. Taylor, S. Boulton, D. Randazzo, A. Desjardins, G. Vlahovic, D. Bigner, H. Friedman
Institution
Duke University Medical Center, Durham, NC, USA
Link
Abstract

At diagnosis and throughout disease course, patients with high-grade glioma (HGG) experience a diminished quality of life (QoL), increase in fatigue, and reduction in cognition. Naltrexone, an orally semisynthetic opiate antagonist, is FDA-approved for treatment of heroin/ alcohol addiction, and Low Dose Naltrexone (LDN) has been observed to improve QoL and lower fatigue in other neurological illnesses, such as multiple sclerosis. LDN is believed to function as a partial agonist and can lead to shifts in neurochemicals that reduce fatigue. Based on this, we sought to study whether LDN has an impact on QoL, fatigue, sleepiness, and cognition in patients with HGG. In a placebo-controlled, double-blind, randomized study, 110 HGG patients were randomized to receive placebo (N=56) or LDN 4.5 mg orally at night (N=54). Treatment was initiated at day 1 of concurrent radiation and temozolomide and continued for 16 weeks. Change from baseline was evaluated in all study assessments including patient-reported outcomes of QoL (Functional Assessment of Cancer Therapy-Brain), fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue), sleepiness (Epworth Sleepiness Scale), depression (Beck Depression Inventory II), and cognitive testing. Safety of LDN was monitored with standard laboratory testing and adverse event reporting. Demographics were WHO grade IV (85%), male (56%), KPS 90-100 (51%), grossly resected (55%) and mean age of 56 years. For all QoL, fatigue, depression, and cognition measures, change from baseline at 16 weeks was not significantly different in patients receiving LDN or placebo. At 16 weeks, LDN patients reported a significantly greater increase in sleepiness from baseline compared to placebo (p=0.0088). Adverse events were seen in similar frequencies for LDN and placebo. Of note, overall survival did not significantly differ between treatment groups. While LDN is safe to administer, LDN has no effect on QoL, fatigue, cognition, or survival, but may increase sedation, in HGG patients.

cbd oil: super snouts molecule simple definition hemp seed oil cystic acne green roads cbd clear high potency cbd gummies sizzix big shot plus cbd for diabetic neuropathy cbd beneficios 10 mg cbd gummies cbd vape side effects cbd spray for sleep does cbd oil enhance your high can you buy cbd in texas spectrum reviews florida cbd non psychoactive ha tag molecular weight boxing gyms melbourne cbd buy cbd oil for pain easily definition dbc natural holistic health center dab drug side effects persian restaurant melbourne cbd stuff to look at high weed bust gw law health insurance best cbd gummies for pain can police use cbd oil cbd oil oklahoma no effect from cbd oil diamond cbd vape cbd oil legal in minnesota is cbd oil illegal anywhere cbd oil legal in va 2018 cbd oil minnesota

vape: best oil vape pen 2017 e cigarette best battery life pure vape pen how to use customs sent ecig back to china from usa best dry herb vape tank e cigarette forum health vape mod protectors cbd store near me vape blows up in guys mouth uwell crown 2 in studies ziggys smoke shop cosmic fog the shocker lower vapor pressure smok vape brand nike vapor bookbag best mechanical mod e cig vapor smoking side effects vapor ingredients ecig outlet muskegon mi e smoker shop vaping health benefits dna ecig dead rabbit rta ingredients of vape juice harsh throat hit vape big smoke meme sigelei 100w specs subtank vape best mr salt e flavor distilled water tugboat vape box mod nicotine less e juice voopoo vinci app weed e cigarette

weight loss: weight loss exercise plan ketosis weight loss before and after anxiety weight loss xtreme 5000 diet pills reviews transformations weight loss brandi and kandi weight loss portion control for weight loss primatene weight loss weight loss plans that work mama june weight loss before and after iodine benefits weight loss weight loss lunches 30 10 weight loss for life recipes medicines that cause weight loss antibiotics weight loss weight loss jump rope healthy weight loss foods nutrisystem for weight loss balsamic vinegar weight loss postpartum diet pills weight loss shoe weight loss pills japan 1200 calories per day weight loss quick weight loss exercises for thighs another word for weight loss alli weight loss pills side effects medi weight loss blog top diet pills sold in stores buy weight loss pills is ultra fast keto boost a scam weight loss on paleo diet fast weight loss programs healthy diet supplements weight loss best post workout drink for weight loss

male enhancement: best foreplay for her ingredient comparison best erectile dysfunction pill what is ginseng used for is it possible to make your dick bigger alternative drugs signs of penis growth penice enlargement what is the average size male penis increase male sex drive penis sizer ways to foreplay all natural test booster male enhancement black snake american average dick size flaccid dicks how to get eraction p6 extreme side effects corpus cavernosum definition how to get a bigger but naturally anxiety disorder quizlet best male supplement big wiener boosting testosterone how long do boners last sexy stores penis enhancement reviews super macho pills top memory pills penis types instinct male enhancement does losing weight increase size male enhancement fda approved vitamin d libido