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Research

Low Dose Naltrexone in the Management of Ehlers-Danlos Syndrome Associated Pain

Title
Low Dose Naltrexone in the Management of Ehlers-Danlos Syndrome Associated Pain
Publication Type
Abstract/Poster/Letter
Research Type
Human
Reported as
Case Report/Series/Restrospective Study
Date
April 19, 2018
Authors
Sean Ormond
Institution
Rush University
Link
Abstract

This is a case of a 35 year old female with history of Ehlers Danlos syndrome, small fiber neuropathy in her left lower extremity, and lumbar radiculopathy who presented to our pain clinic suffering from chronic widespread muscular and joint pain along with persistent neuropathic pain in the lower extremity. Her pain regimen included anticonvulsants, narcotics, and NSAIDS. Over time, her pain regimen as described was inadequately controlling her pain. She was weaned off her narcotics and started on the low dose naltrexone therapy (4.5mg per day). The patient had excellent response with reduction in her pain severity and increase in her daily functionality. At 12 months follow up, she continues to report excellent symptom control without any escalation in adjuvant medications and has resumed her occupation. The patient has tolerated the therapy without any adverse side effects.