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Metronomic chemotherapy for advanced diffuse hepatocellular carcinoma in a dog

Metronomic chemotherapy for advanced diffuse hepatocellular carcinoma in a dog
Publication Type
Journal Article
Research Type
Reported as
Case Report/Series/Restrospective Study
December 20, 2021
Paloma Helena Sanches da Silva, Mayara Coutinho Carlos de Souza, Ellen Bethânia de Oliveira Cavalcanti, Victoria Bringhenti, Fonseca, Tatiany Luiza Silveira, Mayra Cunha Flecher, Geovanni Dantas Cassali, Rodrigo dos Santos Horta
Federal University of Minas Gerais, University Vila Velha, Qualittas College

Primary liver tumors represent 0.6% to 1.3% of neoplasms in dogs. Hepatocellular carcinoma (HCC) is the most common liver tumor. It is divided into three morphological groups: massive, nodular and diffuse. The presumptive diagnosis is made through imaging tests, such as ultrasound, although confirmation is made by histopathology. Surgery remains the treatment of choice for massive tumors, but there is no standard treatment for nodular and diffuse forms. This study aimed to report a case of prolonged survival in a dog with diffuse HCC, treated with metronomic chemotherapy and palliative care including non-steroidal anti-inflammatory and low-dose naltrexone.

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