Find us on:

Research

Naltrexone and Scopolamine Rapidly Reduce Symptoms of Major Depressive Disorder (MDD): A Double Blinded Randomized Controlled Pilot Study

Title
Naltrexone and Scopolamine Rapidly Reduce Symptoms of Major Depressive Disorder (MDD): A Double Blinded Randomized Controlled Pilot Study
Publication Type
Journal Article
Research Type
Human
Reported as
Clinical Trial
Date
February 01, 2019
Authors
Neal Taub
Institution
The Charlotte Ketamine Center
Link
Abstract

BACKGROUND: Scopolamine and naltrexone are FDA approved medications that have been utilized off label for the indication of major depressive disorder (MDD). We examined the efficacy of the 2 medications in combination for major depression.

METHODS: 14 adults (7 female and 7 males) with current major depressive disorder were randomized by coin flip to 0.15 mg BID of scopolamine and 1 mg BID naltrexone or placebo for a total of 4 weeks. Modified MDRS questionnaires were utilized to monitor progress in depression symptomatology. The placebo patients were crossed over to the active medi-cations subsequent to the 4 week trial period.

RESULTS: 2 subjects dropped out of the trial as a result of side effects. A total of 12 subjects completed the trial. The average reduction in Modified MDRS scores over the 4 weeks for the active medications was 12.5. The average reduction noted in control patients was 3.5. This difference was statistically significant with P = 0.03, less than 0.05 for a greater than 95% confidence interval utilizing Student’s T test analysis. Of the 4 patients that crossed over to the active medications three additional patients noted a partial or complete response to the medications with an average reduc-tion and Modified MDRS scores of 8. No washout periods were utilized before the trial or for the crossover period.

CONCLUSION: The combination of scopolamine and naltrexone demonstrated significant benefit for MDD.

male enhancement: 21 natural sex one more knight wholesale how to make your penis thicker erectile dysfunction advertisement average penile length by age 14 erect penis enlargements that work get my cock hard zyrtec erectile dysfunction most powerful testosterone boosters ebay male enhancement rseven male enhancement reviews no morning wood low testosterone kaboom pills testosterone results harder erection can you increase your penis size l arginine erectile dysfunction dosage can cialis be taken with food dysfunction psychology definition best ways to last longer in bed big fat hard cock how to increase semen volume reasons to have sex trouble staying erect entengo herb gnc store near me what are boners l arginine penis enlargement

cbd oil: cbd for horses side effects of hemp oil cbd oil erie pa too much cbd cbd depression reddit pense en ingles boneyard elixir does cbd oil make you gain wieght oc pharm cbd cad cbd tincture northern lights cbd cbd cannabinol cbd oil medical uses fda cbd schedule 1 drug cbd unlimited walgreens cannabis cures list cannabidiol legal coumadin side effect what does thc stand for in weed online cannabis school i have a bad case of diarrhea cbd lab results bear spray stand plant where do you get cbd oil in fort collins no thc too much cbd reddit california arrest for cbd oil what can hemp be used for

weight loss: medical weight loss oatmeal benefits weight loss keto calculator for weight loss walgreens pills to lose weight epsom salt detox bath weight loss where can i get diet pills that work 310 shake weight loss exogenous ketones for weight loss weight loss camp adult 90 day weight loss cigna weight loss surgery sweet potato weight loss sudden weight loss cause 8 week weight loss challenge 100 squats a day weight loss diet shakes for weight loss weight loss pills stomach dr oz diet pills reviews biggest loser diet pills tom hanks castaway weight loss quick weight loss center rosenberg tx weight loss workouts gym leanfire xt results safest weight loss pill xtreme garcinia cambogia effect of diet soda on weight loss garcinia cambogia pure weight loss plateau reddit

vape: puff vape pen smok alien 220w tc manual exhale vape shop smok mesh good vape boxes why does vape juice turn red logic pro ecig review cloud vape aqua bubbler joyetech ecig ecig central longview city journal vaping charleston ecig summerville sc benefits of vaping over smoking how much do vapes cost does vaping raise your blood sugar 3mg nicotine best box mod for sub ohm vape pen types sigelei kaos user manual nike mens air vapor advantage tennis shoes stainless steel uwell temp control square e cigarette uwell crown prime coil nicotine mg in cigarettes lighted vape mods voopoo clapton coil smok voopoo drag says how to fix timeout get weird vape shop