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Research

Low Dose Naltrexone therapy in multiple sclerosis

Title
Low Dose Naltrexone therapy in multiple sclerosis
Publication Type
Journal Article
Research Type
Human
Reported as
Opinion
Date
January 01, 2005
Authors
Agrawal YP
Institution
The University of Iowa
Link
Abstract

The use of low doses of Naltrexone for the treatment of multiple sclerosis (MS) enjoys a worldwide following amongst MS patients. There is overwhelming anecdotal evidence, that in low doses Naltrexone not only prevents relapses in MS but also reduces the progression of the disease. It is proposed that Naltrexone acts by reducing apoptosis of oligodendrocytes. It does this by reducing inducible nitric oxide synthase activity. This results in a decrease in the formation of peroxynitrites, which in turn prevent the inhibition of the glutamate transporters. Thus, the excitatory neurotoxicity of glutamate on neuronal cells and oligodendrocytes via activation of the alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid class of glutamate receptor is prevented. It is crucial that the medical community respond to patient needs and investigate this drug in a clinical trial.