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Low-Dose Naltrexone for multiple sclerosis and autism: Does its benefit reveal a common cause?

Title
Low-Dose Naltrexone for multiple sclerosis and autism: Does its benefit reveal a common cause?
Publication Type
Journal Article
Research Type
Human
Reported as
Opinion
Date
January 01, 2006
Authors
Peter Good
Institution
Link
Abstract

Agrawal proposed that Low-Dose Naltrexone helps multiple sclerosis patients by reducing the activity of inducible nitric oxide synthase, thought responsible for harmful concentrations of the inflammatory molecule nitric oxide in MS brains. It is no coincidence, I believe, that Low-Dose Naltrexone has also helped patients with autism. The rationale for this treatment is that Naltrexone antagonizes endogenous opiods, which are suspected to play a role in autistic behavior, but because levels of nitric oxide are also high in patients with autism, the benefit of Naltrexone in both disorders may be primarily antiinflammatory.