Find us on:

Research

Low-Dose Naltrexone therapy improves active Crohn's disease

Title
Low-Dose Naltrexone therapy improves active Crohn's disease
Publication Type
Journal Article
Research Type
Human
Reported as
Clinical Trial
Date
April 01, 2007
Authors
Smith JP, Stock H, Bingaman S, Mauger D, Rogosnitzky M, Zagon IS.
Institution
Pennsylvania State University
Link
Abstract

OBJECTIVES: Endogenous opioids and opioid antagonists have been shown to play a role in healing and repair of tissues. In an open-labeled pilot prospective trial, the safety and efficacy of Low-Dose Naltrexone (LDN), an opioid antagonist, were tested in patients with active Crohn's disease.

METHODS: Eligible subjects with histologically and endoscopically confirmed active Crohn's disease activity index (CDAI) score of 220-450 were enrolled in a study using 4.5mg Naltrexone/day. Infliximab was not allowed for a minimum of 8 weeks prior to study initiation. Other therapy for Crohn's disease that was at a stable dose for 4 weeks prior to enrollment was continued at the same doses. Patients completed the inflammatory bowel disease questionnaire (IBDQ) and the short-form (SF-36) quality of life surveys and CDAI scores were assessed pretreatment, every 4 weeks on therapy and 4 weeks after completion of the study drug. Drug was administered by mouth each evening for a 12 week period.

RESULTS: Seventeen patients with a mean CDAI score of 356 +/- 27 were enrolled. CDAI scores decreased significantly (P=0.01) with LDN, and remained lower than baseline 4 weeks after completing therapy. Eighty-nine percent of patients exhibited a response to therapy and 67% achieved a remission (P < 0.001). Improvement was recorded in both quality of life surveys with LDN compared with baseline. No laboratory abnormalities were noted. The most common side effect was sleep disturbances, occurring in seven patients.

CONCLUSIONS: LDN therapy appears effective and safe in subjects with active Crohn's disease. Further studies are needed to explore the use of this compound.

cbd oil: cbd half life definition of compund how to make cbd tincture legal limits of thc in cbd oil idaho cbd oil while pregnant cbd oil reclassified lazarus naturals reviews cheapest cbd isolate best wattage to vape cbd trulieve tampa thc cbd vape pen cbd pathway showgirls brisbane cbd cbd oil and the treatment of alzheimers seizure in spanish cbd oil negative effects marijuana substitute spectrum elderly discount cbd oil helping menstrual cycle life force source naturals

male enhancement: advantage care physicians flushing good penis size do penis pumps actually work discomfort in tip of penis get bigger dick penis enlargement surgery los angeles how to grow your peni naturally free prime weight loss pills brain pill cnn all natural testosterone supplements where to buy pandora penis implant cost jacked up supplement how to get a woman in the mood sx power co foods for libido sexual vitality dapoxetine and sildenafil leydig cells definition super male t reviews

vape: pipe style vape alien piss 3 blowing vape rings usa smoke shop drip pen vape dabbler vape pen smok vape pen plus starter kit halo e cigarette coupon moon mountain vapor wismec motiv pod why does my vape juice burn my throat vape glass tank kat timpf vaping tumi vapor international carryon vaporesso polar 220w fireluke 2 coils voopoo alpha zip my vapor store e cigarette store miami voopoo drag 2 open how to update the voopoo drag 2 firmware

weight loss: psyllium husk weight loss weight loss multivitamins weight loss challenge ideas marathon keto pills reviews weight loss menu do acai pills help you lose weight freeze weight loss adderall for weight loss in adults kombucha weight loss before and after conor mcgregor weight loss diet green tea weight loss diet pills in canada that work beaumont weight loss clinic weight loss and menstrual cycle quick weight loss apps calculate calorie for weight loss shred diet pills natural water weight loss pills weightloss diet pill endomorph weight loss success stories