Find us on:

Research

The effect of Low-Dose Naltrexone on quality of life of patients with multiple sclerosis: a randomized placebo-controlled trial

Title
The effect of Low-Dose Naltrexone on quality of life of patients with multiple sclerosis: a randomized placebo-controlled trial
Publication Type
Journal Article
Research Type
Human
Reported as
Clinical Trial
Date
August 01, 2010
Authors
Sharafaddinzadeh N, Moghtaderi A, Kashipazha D, Majdinasab N, Shalbafan B.
Institution
Jondi-Shapoor University of Medical Sciences
Link
Abstract

BACKGROUND: Low-Dose Naltrexone (LDN) may promote psychological well-being as well as generalized health especially in autoimmune disorders. The objective of this study is to assess the effect of LDN on the Quality of Life (QoL) of patients with relapsing-remitting and secondary progressive multiple sclerosis (MS) using the scales and composite scores of the MSQoL-54 questionnaire.

METHODS: A 17-week randomized, double-blind, placebo-controlled, parallel-group, crossover-design clinical trial was conducted in two universities. A total of 96 adult patients aged between 15 and 65 years with relapsing-remitting (RR) or secondary progressive (SP) clinically definite MS with disease duration longer than 6 months enrolled into the study. The primary outcome of the study was comparison of the scores of physical and mental health by conducting independent t-test of the results obtained in the middle and at the end of study between the two groups.

RESULTS: Variables including presence of pain, energy, emotional well-being, social, cognitive, and sexual functions, role limitation due to physical and emotional problems, health distress, and overall QoL did not show any meaningful statistically difference between the two groups. Factor analysis revealed that health perception scores were statistically different between the groups before starting, in the middle, and at the end of the study.

CONCLUSION: The study clearly illustrates that LDN is a relatively safe therapeutic option in RRMS and SPMS but its efficacy is under question and probably a long duration trial is needed in the future.

weight loss: diet tips for fast weight loss weight loss success johnson city weight loss juicing plan weight loss clinics orlando dark chocolate and weight loss weight loss help master cleanse weight loss 3 days weight loss camp for kids ninja smoothies for weight loss dhea benefits weight loss weight loss pills while pregnant how many steps per day for weight loss potent weight loss pills 45 weight loss clinic best selling diet pills that work new prescription diet pills for 2012 diet pills suppliers diet pills doctor max fusion keto cleanse pills eating coconut oil for weight loss

male enhancement: healthy libido muse ed drug how to enlarge your penis naturally shape of hcl pills to grow your penis buried penis surgery wrist thick cock low sex drive after baby how to make penis huge get antibiotics online penis size teens sex on a snowflake drink teenage erectile dysfunction noxitril free offer i want to have sex all the time do you need prescription for viagra best food for men overall extenders vigor natural health clinic how do i make my cock bigger

vape: red vape the vapor club where to buy vape coils smok alien wraps induction vape cheap vape sets ipv4 box mod cbd vape effects reddit e cigarette shocking news e vapor cigarette health risks smok al85 coils amazon cbd vape cartridge near me smok basic kit when did vaping first start my uwell crown is leaking biggest vape store online uwell crown 3 mini sub ohm tank by uwell strong flavor e juice voopoo drag feels clogged voopoo a1 love mode

cbd oil: buy cbd oil with thc how much cbd oil orally under tongue cbd on ultrasound does cbd increase appetite volunteer melbourne cbd cbd store columbus ga what does cbd isolate taste like rheumatoid arthritis medications is cbd oil a depressant heavy harvest cbd hash house a go go menu shop doterra usa define mind and body cbdt e payment herbal plus products cbd oil erectile dysfunction reddit do you ingest cbd oil most reputable cbd oil companies taking high ammounts of cbd oil walmart tomah cbd oil