Find us on:


Low-Dose Naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin

Low-Dose Naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin
Publication Type
Journal Article
Research Type
Reported as
July 01, 2011
Donahue RN, McLaughlin PJ, Zagon IS.
Pennsylvania State University

Ovarian cancer is the leading cause of death from gynecological malignancies. Although initial therapeutic modalities are successful, 65% of these women relapse with only palliative treatments available thereafter. Endogenous opioids repress the proliferation of human ovarian cancer cells in vitro, and do so in a receptor-mediated manner. The present study examined whether modulation of opioid systems by the opioid antagonist Naltrexone (NTX), alone or in combination with standard of care therapies (taxol/paclitaxel, cisplatin), alters human ovarian cancer cell proliferation in tissue culture and tumor progression in mice. Administration of NTX for six hours every two days, but not continuously, reduced DNA synthesis and cell replication from vehicle-treated controls in tissue culture. Moreover, brief exposure to NTX in combination with taxol or cisplatin had an enhanced anticancer action. Mice with established ovarian tumors and treated with a low dosage of NTX (LDN), which invokes a short period of opioid receptor blockade, repressed tumor progression in a non-toxic fashion by reducing DNA synthesis and angiogenesis but not altering cell survival. The combination of LDN with cisplatin, but not taxol, resulted in an additive inhibitory effect on tumorigenesis with enhanced depression of DNA synthesis and angiogenesis. LDN combined with cisplatin alleviated the toxicity (e.g. weight loss) associated with cisplatin. LDN treatment upregulated the expression of the opioid growth factor (OGF, chemical term ([Met(5)]-enkephalin) and its receptor, OGFr. Previous tissue culture studies have reported that OGF is the only opioid peptide with antiproliferative activity on ovarian cancer cells, with OGF action mediated by OGFr. Thus, the common denominator of intermittent opioid receptor blockade by short-term NTX or LDN on ovarian cancer proliferation and tumorigenesis recorded herein appears to be related to the OGF-OGFr axis. These preclinical data may offer a non-toxic and efficacious pathway-related treatment that can benefit patients with ovarian cancer.

vape: mango vape juice stingray vapors dimitri vape eleaf istick pico 75 sriracha vape juice how many people have died because of vaping ecig vaporizer pen cool vapes for sale akemi expansions vape juice reddit ecig forum e cigarette burns liquid vape phoenix az century 21 e cigarette cartridges small box mods r vaping ecig store locator cascade vaporesso coils the kiln user guide ecig tanks on mech mods pod alternative what coil does uwell crown come with vaporizer pen stores near me voopoo too mod chip vape store canada

male enhancement: cialis substitute sex drive enhancers male us online pharmacy viagra gnc male performance exercises to make dick bigger erectile dysfunction supplement male dicks viagra dosage for bph gnc test boosters large flaccid cock herbal cialis what is blue pill tadalafil cost how much are testosterone injections clarithromycin side effects reviews vasodilators drugs sexual dysfunction meaning half life of viagra what to do with an erection foods that increase testosterone levels uncircumcised penises photos low dose testosterone true grit test booster impotency definition

cbd oil: cbd oil and birth control liver metabolism of drugs beezbee cbd oil where to buy cbd plants cbd oil show up on drug tests where to buy green roads cbd oil near me cbd oral spray for pain benefits of cannabinoids melbourne australia cbd cbd oil texas austin cbd oil in richmond va flow gel best cbd oil for pain reviews co2 cbd oil 3mg cbd cbd oil charleston medterra coupon codes orange peel cbd oil what does w stand for in oil cbd lemon drops compound information how much to vape cbd oil 50mg med lab supply coupon cbd oil and anxiety study

weight loss: borage oil benefits weight loss best weight loss centers strong weight loss top ephedra diet pills running for weight loss app reviews weight loss pills for belly fat ariana biermann weight loss teen weight loss program elliptical and weight loss metformin weight loss stories weight loss during first trimester silver bullet diet pills girl weight loss before and after weight loss quote images b lite diet pills metformin weight loss diet amphetamine diet pills buy online uk weight loss cardio plan fda approved diet pills for women b4 weight loss pills quick weight loss soup recipe 60 pound weight loss paleo diet weight loss indian medshape weight loss clinics