Find us on:


Safety and tolerability of Low-Dose Naltrexone therapy in children with moderate to severe Crohn's disease: a pilot study

Safety and tolerability of Low-Dose Naltrexone therapy in children with moderate to severe Crohn's disease: a pilot study
Publication Type
Journal Article
Research Type
Reported as
Clinical Trial
April 01, 2013
Smith JP, Field D, Bingaman SI, Evans R, Mauger DT.
Pennsylvania State University

BACKGROUND: There is an unmet need for safe and effective medicines to treat children with Crohn's disease. Recently, investigations have shown an association between endogenous opioid peptides and inflammatory cells. AIMS: The aims of this study were to evaluate the safety and tolerability of an opioid antagonist,Naltrexone, in children with moderate to severe Crohn's disease.

METHODS: A pilot clinical trial was conducted in children with moderate to severe Crohn's disease. Fourteen subjects with a mean age of 12.3 years (range, 8 to 17 y) were enrolled. Children were randomized to placebo or Naltrexone (0.1 mg/kg) orally for 8 weeks followed by open-labeled treatment with 8 additional weeks of Naltrexone. Safety and toxicity were monitored by physical examinations and blood chemistries. Clinical activity was assessed by the Pediatric Crohn's Disease Activity Index (PCDAI) and Quality of life was monitored by the Impact III survey.

RESULTS: Oral Naltrexone was well tolerated without any serious adverse events in children with moderate to severe Crohn's disease. PCDAI scores significantly decreased from pretreatment values (34.2±3.3) with an 8-week course of Naltrexone therapy (21.7±3.9) (P=0.005). Twenty-five percent of those treated with Naltrexone were considered in remission (score ≤10) and 67% had improved with mild disease activity (decrease in PCDAI score by at least 10 points) at the end of the study. Systemic and social quality of life improved with Naltrexone treatment (P=0.035).

CONCLUSIONS: Naltrexone therapy seems safe with limited toxicity when given to children with Crohn's disease and may reduce disease activity.

sex older man how to keep a long erection how long for flomax to leave system what is penis pump erectile dysfunction products when did viagra come out gas relief walmart celexas male enhancement viagra super active 100mg red fortera walmart grow my penis secret sex tube penis ligaments 60 mg cialis too much german penis enlargment teen errection make dick bigger naturally muscle hardening supplements use of penis penis and testis what if viagra doesnt work nugenix pros and cons how much viagra should a woman take kollagen intensiv cheap viagra online usa penis pump exercises supplements that increase blood flow erection on demand can you take too much niacin medicine online what is gainswave men with low sex drives what causes an erection in the morning an average penis peni piercing penis enlargening burst blood vessel in urethra measuring my penis african long dick talk to a dr online free how to get hormones male kegel orgasm side effects of testosterone therapy how to get a really hard erection t bomb extreme little yellow pill reviews zmass testo boost vimax pills results pictures male enhancement alpha q pandora colm

extreme weight loss metabo garcinia diet pills best weight loss app diet pills no exercise roseanne barr weight loss holy grail of weight loss slow weight loss al roker weight loss surgery anemia weight loss metformin hcl weight loss victoza pen for weight loss weight loss fiber pills calorie counter weight loss weight loss herb tea fast weight loss pills that work at home weight loss workouts how to take spirulina for weight loss get rid of loose skin after weight loss doterra weight loss success stories island weight loss clinic start a weight loss blog weight loss beverages drew carey weight loss pictures precious weight loss pics 2017 best cla safflower oil for weight loss 45 pounds weight loss how to brew green tea for weight loss metaboltonics green dmae weight loss dandelion pills for weight loss crash diet for weight loss big pun weight loss best weight loss pills for menopause cheap working diet pills cellucor weight loss pills sean milliken weight loss smoothie king weight loss pills south shore weight loss miracle burn diet pills stool softener weight loss quick weight loss center dunwoody ga diabetic menu for weight loss paleo diet for weight loss meal plan weight loss center chicago uppers pills fun weight loss challenge ideas supplements for fat loss phentermine energy side effects of ultra fast keto boost dr oz weight loss drink

vape no A Tag

cbd oil uses what does cbd vape do ned cbd cbd oil flavored buy online target cbd cbd horse treats dosage of cbd for anxiety best skin care products consumer reports cbd oil for sleep dosage is cbd snake oil cbd kratom combo cbd oil show up on drug tests natures love no thc cbd oil cbd oil and cluster headaches is cbd oil legal in tennessee do you need a medical card to buy cbd in california how long to hold cbd under tongue cbd cream for plantar fasciitis how it says wild hemp brand cbd oil margaret cuomo a world without cancer cbd oil bone healing cbd oil makes me hungry cbd expert cbd popcorn healthy king cbd oil oil m easy definitions spectrum health labs valsartan max dose cbd marijuana extract pain and wellness group cbd 2 to 1 definiton of drug cbd oil for warts thc pills recipe do you need a medical card for cbd apothecanna extra strength quick study medical terminology best way to smoke weed cbd oil dosage for celiac a que in english native hemp solutions cbd oil fm cosmetics cc cream cbd flower for sale online best cbd oil leafly cbd nc cbd oil for immune system can you use cbd htc vape oil under chin