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Treatment of Complex Regional Pain Syndrome (CRPS) using Low Dose Naltrexone (LDN)

Title
Treatment of Complex Regional Pain Syndrome (CRPS) using Low Dose Naltrexone (LDN)
Publication Type
Journal Article
Research Type
Human
Reported as
Case Report/Series/Restrospective Study
Date
June 01, 2013
Authors
Chopra P, Cooper MS.
Institution
Brown University
Link
Abstract

Complex Regional Pain Syndrome (CRPS) is a neuropathic pain syndrome, which involves glial activation and central sensitization in the central nervous system. Here, we describe positive outcomes of two CRPS patients, after they were treated with Low-Dose Naltrexone (a glial attenuator), in combination with other CRPS therapies. Prominent CRPS symptoms remitted in these two patients, including dystonic spasms and fixed dystonia (respectively), following treatment with Low-Dose Naltrexone (LDN). LDN, which is known to antagonize the Toll-like Receptor 4 pathway and attenuate activated microglia, was utilized in these patients after conventional CRPS pharmacotherapy failed to suppress their recalcitrant CRPS symptoms.