Find us on:


Low Dose Naltrexone: Side Effects and Efficacy in Gastrointestinal Disorders

Low Dose Naltrexone: Side Effects and Efficacy in Gastrointestinal Disorders
Publication Type
Journal Article
Research Type
Reported as
Case Report/Series/Restrospective Study
March 01, 2010
Ploesser J, Weinstock LB, Thomas E.
St. Louis College of Pharmacy

Use of Low Dose Naltrexone has been advocated for a variety of medical problems. Only a few articles published in peer review journals have documented side effects of Low Dose Naltrexone. The purpose of this study was to determine the frequency of adverse effects of Low Dose Naltrexone in patients who have been treated for a variety of gastrointestinal disorders. The secondary purpose was to determine global efficacy in a retrospective survey. Patients (206) form a single gastroenterologist's clinical practice who had been prescribed Naltrexone were mailed a survey to evaluate the side effects and efficacy of Naltrexone. Patients had either irritable bowel syndrome without evidence for small intestinal bacterial overgrowth, chronic idiopathic constipation, or inflammatory bowel disease. Patients with diarrhea were given 2.5 mg daily, constipation 2.5 mg twice daily, and inflammatory bowel disease 4.5 mg daily. In the patients who returned the survey, 47/121 (38.8%) had no side effects. Of the 74/121 (61.2%) patients who had side effects, 58 had one or more neurological complaints, and 32 had one or more gastrointestinal side effects. In the patients with side effects, 24/74 (32.4%) had short lived symptoms. Low Dose Naltrexone was terminated owing to side effects in 20/74 patients (27.0%). In 13 patients with idiopathic irritable bowel syndrome, 2 were markedly worse. In 85 patients with irritable bowel syndrome-small intestinal bacterial overgrowth, 15 were markedly improved, 32 were moderately worse, and 1 was markedly worse. In 12 patients with chronic constipation, 7 were markedly improved, 1 was moderately improved, 1 was mildly improved, and 4 were unchanged. Low Dose Naltrexone frequently has side effects but in most is tolerable. It appears to be helpful for a number of patients with gastrointestinal disorders.

male enhancement: why has my sex drive decreased how to get a bigger penis naturally pill review food for rhino tadalista review real viagra online mail order prescriptions from canada how to stay erect longer without pills how to increase flaccid size penis volume 1 male enhancement pills sudafed erectile dysfunction vaccum sex strong sex foods to increase testosterone sizerect ultra pills norvir side effects cialis 5mg side effects how to open blood vessels naturally things to help erectile dysfunction restart puberty chain does penis enlargement work lamictal erectile dysfunction inhouse pharmacy reviews define obliging why do i have bumps on my penis rock hard weekend reviews penile sleeve type of penis longjack dose foreskin sex weekend pill small red dots on penile head can anxiety cause erectile dysfunction penis cap what causes random boners something new to try in bed hong wei pills 3500 mg vitamins to boost appetite pfizer viagra 100mg price grow big penis garlic libido libido pills walgreens i have no sex drive pill extenze show me large penises best sleep aid 2020 penis extension sex

vape: just2 vape vape pen packaging henley vape gypsy vape juice vape delivery city super mini e cigarette real thc vape juice e cigarette buy vape it up e cigarette cannabis liquid aero mesh tank e cigarette voltage regulator vapor world springfield mo voopoo drag never burn coil vapor expressions atomizer coil build e cigarette charlotte nc flavored vape ban michigan recipe for e cigarette juice e cigarette stores in canada does e cigarette kill cilia mark ten vape dangers of vaping without nicotine m401 e cigarette fda vaping study fox news vaping open pod eleaf mini istick tank best website to buy vapes jawbreaker vape juice the best box mod vaporesso mods best mod boxes smok box smok infinix near me g priv firmware smok tvf8 vapes e juice uwell valerian tank can you clean a voopoo mesh coil coils for uwell mod tank joyetech ego aio manual uwell crown 3 mini glass nicotine salt mods tanks best with voopoo drag triple ego ecig voopoo drag 157w mod kit sigelei kaos vs smok alien

weight loss: 30 day weight loss nutrisystem 7 day weight loss kit phentermine weight loss results supplements for quick weight loss hcg weight loss program yogi green tea kombucha weight loss what cause rapid weight loss slimming weight loss pills 100 lb weight loss before and after vegan weight loss programs lifetime weight loss diet pills high blood pressure weight loss progress charts charlotte weight loss muscle milk weight loss liza weil weight loss weight loss and exercises weight loss diet vegetarians sprintec weight loss h3h3 weight loss jessica simpson weight loss today show is coffee healthy for weight loss weight loss cleansing drink weight loss medication otc keely shaye weight loss weight loss drinks that really work drinking weight loss weight loss programs jacksonville fl levothyroxine 88 mcg weight loss frozen dinner diet weight loss seaweed benefits weight loss face change after weight loss safflower oil weight loss pills acxion side effects top weight loss pills for men diet pills used by celebrities weight loss fiber pills purefit keto pills healthy weight loss pills that work brain octane oil weight loss fibre pills for weight loss top 10 diet pills for women top rated over the counter diet pills diet is 80 percent of weight loss star bodies diet pills weight loss dr in houston alli diet reviews does flaxseed help with weight loss

cbd oil: cbd rich hemp oil apex hemp oil mile marker 5 cbd oil is it good for diabetes cbd cure honey jax cbd oil cbd or thc for cancer walking map of sydney cbd cbd oil reviews 2019 what does cbd do in weed cbd oil back pain reddit cbd oil for ovarian cysts terphouse cbd oil fake id canada cbd and colds naked weed report cbd oil legal louisiana non thc cbd cbd and rls hand and stone estero what is cbd business giant gummy bears cheap can you fly with cbd oil 2018 grand daddy purp cbd street food sydney cbd diamond cbd full spectrum buy cbd oil uk cbd vasodilator cbd oil and blood clots cannabinoid neurotransmitter non cannabis cbd oil cbd oil for macular degeneration amazon call customer service is cbd oil legal in idaho re 19 pill does doterra have cbd oil psoriasis spanish whats the average cost for cbd oil mary j blige new video ackerman pens best medical alert system consumer report cbd prostate cancer treatment best cbd oil for psoriatic arthritis diamond cbd lab results can you bake with cbd oil anti nausea cream pure life cbd oil 1000mg dosage german certified cbd oil