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Low Dose Naltrexone in the treatment of dissociative symptoms

Low Dose Naltrexone in the treatment of dissociative symptoms
Publication Type
Journal Article
Research Type
Reported as
Clinical Trial
November 26, 2014
Pape W, Wöller W.
Krankenhaus für Psychosomatische Medizin und Psychotherapie

BACKGROUND: Following the hypothesis that blocking opioid receptors leads to a decline in opiate-modulated dissociative phenomena, experiences with Naltrexone as medication for dissociative symptoms been gained since 1999 (mainly in doses of 25-100 mg/day).

PATIENTS AND METHODS: In this study patients with severe trauma-related and dissociative disorders were treated with Naltrexone in doses of 2-6 mg/day (0.06 mg/kg body weight).

RESULTS: The low dose treatment with Naltrexone proved to be effective whereby 11 out of 15 patients reported immediate positive effects and seven described a lasting helpful effect. The majority of patients who felt positive effects reported a clearer perception of both their surroundings and their inner life. Assessment of reality and dealing with it improved as did the perception of their own body and affects as well as self-regulation. The treatment was very low in side effects.

CONCLUSION: Treatment with Low-Dose Naltrexone may be a helpful element in the treatment of patients with complex post-traumatic stress disorder. However, it has to be realized that the decrease of dissociation may lead patients to a not yet resolvable challenge, in as much as dissociation had previously been a necessary mechanism of self-protection.