Find us on:

Research

Naltrexone at low doses upregulates a unique gene expression not seen with normal doses: Implications for its use in cancer therapy

Title
Naltrexone at low doses upregulates a unique gene expression not seen with normal doses: Implications for its use in cancer therapy
Publication Type
Journal Article
Research Type
Lab (in-vitro)
Reported as
Date
June 07, 2016
Authors
Wai M. Liu, Katherine A. Scott, Jayne L. Dennis,Elwira Kaminska, Alan J. Levett, Angus G. Dalgleish
Institution
St. George's University of London
Link
Abstract
It has been reported that lower doses of the opioid antagonist naltrexone are able to reduce tumour growth by interfering with cell signalling as well as by modifying the immune system. We have evaluated the gene expression profile of a cancer cell line after treatment with low-dose naltrexone (LDN), and assessed the effect that adapting treatment schedules with LDN may have on enhancing efficacy. LDN had a selective impact on genes involved with cell cycle regulation and immune modulation. Similarly, the pro-apoptotic genes BAD and BIK1 were increased only after LDN. Continuous treatment with LDN had little effect on growth in different cell lines; however, altering the treatment schedule to include a phase of culture in the absence of drug following an initial round of LDN treatment, resulted in enhanced cell killing. Furthermore, cells pre-treated with LDN were more sensitive to the cytotoxic effects of a number of common chemotherapy agents. For example, priming HCT116 with LDN before treatment with oxaliplatin significantly increased cell killing to 49±7.0 vs. 14±2.4% in cultures where priming was not used. Interestingly, priming with NTX before oxaliplatin resulted in just 32±1.8% cell killing. Our data support further the idea that LDN possesses anticancer activity, which can be improved by modifying the treatment schedule.

caffeine weight loss vegan diet weight loss menu wellbutrin xl dosage for weight loss meizi evolution diet pills levothyroxine at night weight loss cize weight loss results water pill weight loss green tea fat burner side effects best cardio for weight loss at the gym weight loss drugs approved by fda lily mae harrington weight loss weight loss appetite suppressant weight loss sleep meditation chinese herb diet pills wellbutrin xl for weight loss most effective weight loss pills at gnc journeylite weight loss potato starch for weight loss can thyroid problems cause weight loss weight loss pills 2016 bulletproof coffee weight loss results weight loss pills for 12 year olds circuit workout for weight loss t3 side effects weight loss weight loss detox pills veggie smoothies for weight loss actress monique weight loss rob kardashian weight loss diet terry hollands weight loss weight loss pills rite aid best cleanses for weight loss and detox plexus slim diet pills diabetic weight loss pill this is us kate weight loss afire diet pills simple weight loss plan confidence diet pills how does wellbutrin cause weight loss cheap pills to lose weight fast diet pills with forskolin sletrokor reviews most effective workout for weight loss shark tank diet products lose weight fast what is the best fat burning pill food chart for weight loss white pill d 25 cayenne pepper weight loss

vape no A Tag

how long before sex do you take viagra daa max gnc how long does sildenafil work herbs that increase testosterone viagra and ejaculation pycnogenol erectile dysfunction a real penis my dick is hard cock grow whats the biggest penis in the world increase blood flow to pennis new male enhancement pills male enchantment pills cialis for sale over the counter abnormally small penis penis enlarging excersise viagra benefits no perscription antibiotics what is the blue pill surgical cost door doctor effects of alcohol sexually for men improve erection strength homemade testosterone warning signs of erectile dysfunction sex house near me what fors status supplement gnc nugenix ultimate testosterone reviews blood flow vitamins jacked supplement uncircumcised dick pictures male std warning signs mayo clinic drugs and supplements penile disorders best male libido pills doctors looking at private parts gnc ultimate testo explosion alpha titan testo ingredients penis enlargement remedy by tom candow blue star nutraceuticals status dry skin on penis head woody male enhancement breast enlargement cream at walmart rhino 5 pill review erectile dysfunction education male enhancement for 21 year old mens sex supplements

buy cbd wax dr report gold drops cbd biomedicine and pharmacotherapy cbd oil india does all weed have cbd cbd oil and xarelto what is pills and potions about is cbd oil legal in kentucky 2017 is cbd oil allowed on airplanes cbd oil and fibroids cbd oil for kids adhd dosage best vape for cbd oil reddit thc oil uses cbd vape tips cannabidiol structure cbd oil causes stroke cbd que es cbd for heart health cbd dispensary no card needed the body shop brisbane cbd cbd flower for sale online best pain relief cbd cbd oil permiyed what states five star hotels melbourne cbd kiehls cbd running stores sydney cbd water soluable cbd is 100 hcb best cbd oil for insents warmer fraction calculator cbd oil peace frog kentucky select tobacco review which is better hemp oil or cbd oil vape oils how long until cbd kicks in traumatic brain injury marijuana where does oil come from 1cbd uk canna caps dosage verified cbd oil for pain adhd medication best cbd oil for adults 600 w oil pain management cats cbd oil advice for taking cbd oil which cbd oil should i buy can you vape tincture cbd oil