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Low dose naltrexone: a novel treatment for Hailey-Hailey disease

Title
Low dose naltrexone: a novel treatment for Hailey-Hailey disease
Publication Type
Journal Article
Research Type
Human
Reported as
Case Report/Series/Restrospective Study
Date
October 09, 2017
Authors
Campbell V, McGrath C, Corry A.
Institution
Belfast City Hospital
Link
Abstract

Hailey-Hailey disease (chronic benign familial pemphigus) is a rare inherited dermatosis typically characterised by erosions at intertriginous sites preceded by minor trauma or stress. We report a case of treatment resistant Hailey-Hailey disease, having failed topical and oral steroids, prophylactic acyclovir and doxycycline, and systemic therapies including dapsone, acitretin and ciclosporin. Low dose naltrexone (LDN) 4.5mg one daily was commenced following an incidental benefit in this patient's similarly affected sister. The clinical and psychological response to date has been considerable.