Find us on:

Research

Low dose Naltrexone for induction of remission in inflammatory bowel disease patients

Title
Low dose Naltrexone for induction of remission in inflammatory bowel disease patients
Publication Type
Journal Article
Research Type
Human
Reported as
Clinical Trial
Date
March 09, 2018
Authors
Mitchell R. K. L. Lie, Janine van der Giessen, Gwenny M. Fuhler, Alison de Lima, Maikel P. Peppelenbosch, Cokkie van der Ent and C. Janneke van der Woude
Institution
Erasmus University Medical Center Rotterdam
Link
Abstract

BACKGROUND: Around 30% of patients with inflammatory bowel disease (IBD) are refractory to current IBD drugs or relapse over time. Novel treatments are called for, and low dose Naltrexone (LDN) may provide a safe, easily accessible alternative treatment option for these patients. We investigated the potential of LDN to induce clinical response in therapy refractory IBD patients, and investigated its direct effects on epithelial barrier function.

METHODS: Patients not in remission and not responding to conventional therapy were offered to initiate LDN as a concomitant treatment. In total 47 IBD patients prescribed LDN were followed prospectively for 12 weeks. Where available, endoscopic remission data, serum and biopsies were collected. Further the effect of Naltrexone on wound healing (scratch assay), cytokine production and endoplasmic reticulum (ER) stress (GRP78 and CHOP western blot analysis, immunohistochemistry) were investigated in HCT116 and CACO2 intestinal epithelial cells, human IBD intestinal organoids and patient samples.

RESULTS: Low dose Naltrexone induced clinical improvement in 74.5%, and remission in 25.5% of patients. Naltrexone improved wound healing and reduced ER stress induced by Tunicamycin, lipopolysaccharide or bacteria in epithelial barriers. Inflamed mucosa from IBD patients showed high ER stress levels, which was reduced in patients treated with LDN. Cytokine levels in neither epithelial cells nor serum from IBD patients were affected.

CONCLUSIONS: Naltrexone directly improves epithelial barrier function by improving wound healing and reducing mucosal ER stress levels. Low dose Naltrexone treatment is effective and safe, and could be considered for the treatment of therapy refractory IBD patients.

vape: philip morris vape nicotine salt calculator open vape battery royalty 2 vapetasia quartz vape pen o2 pure ecig polar vape vapor untouchable 3 400mah battery ecig smok prince leaking tng distribution breathe ecig corp e cigarette blew up pear vape juice candy corn vape juice 901 e cigarette smok e mountain mech works what does vaping smell like uprite vapor priv v8 review aspire vape case variable wattage mod explained terp juice how to change coil smok battery wont charge smok v12 prince triple mesh coil snow wolf 200w black best compilations dna vape mod vaporizer pen sale vape stick mod ultimate vapor e juice ejoy ecig smok mag 225w tc vape crusades uwell nunchaku lock smok alien 220w screen not working uwell calinburn reddit voopoo drag 157w wholesale crown uwell vs herakles plus voopoo drag mini mod only tutorial joyetech evic work with uwell tank the vapor spot replace glass cylinder uwell are you supposed to inhale when you vape uwell crown tank keeps reading temp control on snowwolf smoking vape juice on weed voopoo drag baby trio 25w atomizwe discount smoke shop near me

cbd oil: is cbd oil legal in nebraska cbd oil store in mcallen texas cbd brothers trubliss cbd oil cbd ptsd royal cbd oil review cbd japan cbd certification serviced apartment sydney cbd cbd oil in checked baggage cbd charleston system healer license key free atlanta cbd map quicksilver cbd reviews efficacy of hemp cbd vs marijuana cbd how to use cbd oil with low dose naltroxene can you buy cbd at whole foods cbd oil in florida prices best cbd massage products cbd oil turned pink pain relief cbd oil pga shop coupon code cbd durban poison spectrum health holland cbd oil south bend indiana what is the difference between cbd oil and hemp for pets essential oils snopes cbd oil best value metabolism sentence define psychoactive phoenix tears colorado dispensary axis labs cbd oil what are marijuana tablets cloud e cbd vape oil review magnetic resonance in medicine high cbd and thc strains psychology research of mice and men characters aspire fitness reviews what is oxidative decarboxylation side effect of hand practice definition of dosage tylenol with codeine canada how many people smoke weed cbd oil plants aspire ecig review medically approved cbd oil suboxone and cbd oil

male enhancement: sex personal questions driv fitness what is low sex drive best brain supplements for adults taking clomid nitric acid supplement taking half a viagra top sex tips where can i buy a penis pump drugs sex cialis 20 mg street value numbness during sex penis extensions newgenics at gnc realistic penis extender lil float erectile dysfunction the penis bible how long is the average size penis what is jelqing and how does it work anti depression perfect size pennis impotence pill massive long dick anxiety and sex drive best testosterone supplement review swag male enhancement ageless male gnc best muscle building stacks 2020 jet pro x reviews brazzers exercise your cock do i have erectile dysfunction dick skin best time to take citrulline average penis size stronger erections naturally manscaping penis how to get erections why do guys get erections hims review reddit sexually fluid meaning girls have sex geisha pills zyalix scam testosterone blocking herbs alpha monster reviews herbs for penis growth male enhancement coach review how can i get my dick bigger

weight loss: weight loss surgery for low income green tea with lemon weight loss detox cleanse weight loss is the paleo diet good for weight loss vitamin b12 shots for weight loss largest weight loss shakeology reviews for weight loss fairmont weight loss clinic weight loss cartoons diuretic pills for weight loss does magnesium help with weight loss antidepressant that causes weight loss thrive weight loss patches top of the line diet pills 3010 weight loss cost new weight loss treatment affordable weight loss programs dr oz on diet pills hormones weight loss appetite suppressants that work kris jenner weight loss gabrielle anwar weight loss food diary for weight loss weight loss physicians near me weight loss by body type does zetia cause weight loss 30 day challenges for weight loss ace diet pills distributors best pills weight loss weight loss pills breastfeeding v3 weight loss pills meditation and weight loss skinny gal weight loss pills self sabotaging weight loss diet pills that work for men advocare weight loss program ace diet pills walmart gary shirley weight loss mega green tea diet pills cayenne pepper tea for weight loss fast diet pills for women ephedrine pills weight loss acai berry diet pills oprah queen diet pills successful diet plans for weight loss safe all natural weight loss pills best garcinia cambogia pills weight loss medication