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Successful treatment of dermatomyositis with low-dose naltrexone

Title
Successful treatment of dermatomyositis with low-dose naltrexone
Publication Type
Journal Article
Research Type
Human
Reported as
Case Report/Series/Restrospective Study
Date
September 24, 2018
Authors
Thanh Tran, Alessandra Chen, Scott Worswick
Institution
UCLA
Link
Abstract

Low-dose naltrexone has been shown to treat autoimmune conditions, such as multiple sclerosis, fibromyalgia, and Crohn's disease. We present two cases in which low-dose naltrexone proved an effective therapy for dermatomyositis (DM), an idiopathic inflammatory myopathy. A search of PubMed for “low dose naltrexone” and “dermatomyositis” did not reveal any reported cases of the use of low-dose naltrexone in DM. We suspect that low-dose naltrexone produces an antiinflammatory effect via inhibition of toll-like receptor 4 (TLR4) and augmentation of endogenous opioid production. Low-dose naltrexone as treatment for DM is promising, as the cost of the medication is low, and its adverse effects are minimal.