Find us on:


Variable response to low-dose naltrexone in patients with Darier disease: a case series.

Variable response to low-dose naltrexone in patients with Darier disease: a case series.
Publication Type
Journal Article
Research Type
Reported as
Case Report/Series/Restrospective Study
February 03, 2019
D. Boehmer, K. Eyerich, U. Darsow, T. Biedermann, A. Zink
Technical University of Munich

BACKGROUND: Darier disease is a rare autosomal-dominant genodermatosis with a loss of function of a Ca2+ -ATPase pump (SERCA2-pump). Clinically, the disease is characterized by red-brown keratotic papules mainly in seborrheic areas and has only limited and unsatisfactory treatment options. Previously, low-dose naltrexone was described as a successful treatment option in Hailey-Hailey-disease, a genodermatosis with a genetic mutation coding for a similar loss of function of a Ca2+ -ATPase pump (hSPCA1-pump).

OBJECTIVE: To assess the efficacy of low-dose naltrexone as a treatment option in Darier disease.

METHODS: Six patients with biopsy-proven Darier disease (4 had severe, 1 had moderate and 1 mild clinical manifestations). The patients received off-label therapy with naltrexone (5 mg per os [p.o.]) and magnesium (200 mg p.o.). Patients were followed up every 4 weeks for minimally 12 weeks. Upon clinical presentation, the disease severity and subjective pain and itch scores were assessed, and standardized photographs were obtained.

RESULTS: The clinical response to naltrexone varied after 12 weeks. The 4 patients with severe Darier disease showed worsening after initial improvement during the first 4 weeks, whereas the 2 patients with a mild to moderate clinical manifestation clearly improved, showing almost full remission after 12 weeks with complete flattening of the keratotic papules.

CONCLUSION: Low-dose naltrexone did not have an effect on severe Darier disease compared to Hailey-Hailey disease, but it was beneficial in mild to moderate forms of the disease. Further studies are needed to confirm these observations of variable responses.

weight loss: youtube weight loss meditation top 5 diet pill blue weight loss pill cheap alli diet pills uk x life weight loss m 375 pill medical weight loss by healthogenics catalyst diet pills red wine vinegar weight loss how to portion food for weight loss fitness programs for weight loss diet foods for weight loss group weight loss challenge app skinny weight loss tea benefits of cryotherapy weight loss good and safe weight loss pills 4 month weight loss before and after yanhee hospital diet pills honey boo boo weight loss 2017 diet pills prescribed by a doctor truvision weight loss pill cellucor diet pills diabetes drug for weight loss weight loss progression chart cnn student weight loss tea weight loss diet weight lifting fat loss how to get free weight loss surgery amy freeze weight loss ideal weight loss naperville kickboxing weight loss before and after medical weight loss centers weight loss and pco phentermine diet pills amazon fast weight loss pills that work red tea for weight loss pre workout for women weight loss natural herbal weight loss pills weight loss with prozac foreskin diet pills l a weight loss products benefits of dates in weight loss prilosec weight loss vegan diet for weight loss menu quick cheap weight loss pills bcaa for women weight loss beat diet pills pur cambogia dexatrim green tea diet pills best weight loss program 2018 diet no weight loss solo weight loss pills diet patches weight loss bitter gourd diet pills elimination diet for weight loss ultra fast keto boost where to buy

vape: leap vape how long can you use ecig coils for tgi vape e cigarette forum videokarma 300mg cbd vape pen do you gain weight when you stop vaping diy vape juice supplies good battery for uwell crown prebuilt vape coils what vg amount can the uwell crown use luckys vape wichita ks what tank is everyone using on the voopoo drag mini free vape pens the best vapor tank vape shops in ogden utah recurve drip tips blu ecig review 1 uwell crown ecig calculator app best budget dry herb vape us made vape juice vuse solo instructions vampire vape juice smok t8 baby beast coils how to make vape juice sweeter uwell crown keeps burning coils vape e juice kit vaping runny nose craft vape nicotine poisoning from vaping disposable e cigarette with nicotine vapor shark pen e cigarette carcinogen vaping pen for cbd oil nude top 100 vape allergy smok alien 220w mod kit uwell crown coils ni200 and tank best vape pen mods ecig lounge waite park voopoo too manual e cigarette nicotine buy best vapor juice flavor vapor oil rba rebuild kit best ejuice calculator caliburn uwell xtreme vaping nicotine sure vapes nike vapor untouchable review t priv review vapor drawings smok helmet coils beat mods voopoo too u2 coil how to adjust ohms on smok mag

cbd oil: cbd for adhd thc and testosterone cbd isolate vs full spectrum cv sciences plus cbd oil amazon cbd oil manufacturers what is hemp used for medically cbd for parkinson best starting cbd oil how many ml in a gram of oil cbd oil did nothing for me phytocannabinoid vs cbd cbd oil gnc do you smoke cbd f45 ballarat cbd cbd stage 4 pancreatic cancer oregon cbd company is cbd good for sore muscles what does it mean to minimize a function body mod organics hemp seed oil with full spectrum cbd for sale seizures wiki one gram of cbd oil prog neuropsychopharmacol biol psychiatry ameo cbd patch zija seizure translate in spanish crown caps cbd thc pills side view drawing reference cvs coupons cbd oil negative side effects artisan canna cigars purekana cbd alana blanchard interview federal law cbd oil can you eat cbd oil i am the alpha and the omega neuroprotective effects cbd oil cancer dosage d mart cbd belapur full extract cbd oil for sale elixinol cbd oil amazon cbd 3000mg gummies cbd oil for pain for sale near me is hemo oil the same as cbd cbd oil anxiety reviews the farm bill cbd cbd oil for copd mayo clinic simpson oil uses tjs cbd oil hemp news where to buy pure cbd hemp oil sublingual indica with cbd oil can i take cbd oil abroad with me 3mg cbd what is the differernce between hemp oil and cbd oil cbd define

male enhancement: how to reduce sex drive in males viagra altitude sickness mens sex pills making ur dick bigger viagra contraindications how to build stamina in bed definition of viagra reasons for low sex drive vacuum pump sex penis supplement sex stimulant for male penis pumping before and after how to get a bigger penus make penis thicker is penis growth possible viagra girl 2020 how to increase penis length naturally how to take a big penis girth dicks gnc pharmacy near me gnc workout supplements how to enhance sex drive green and yellow pills extend pills extenze pills cvs cialis free trial coupon race and penis size animal test reviews increased sex drive in early pregnancy penis product viagra high blood pressure google penis over the counter viagra canada big cock growing what is dysfunction low libido in young man prices viagra when is testosterone highest enhancment drugs enhancement male anaconda xl pills pubert penis tribulus terrestris review best instant male enhancement pills libigirl pills ginkgo biloba penis applied nutrition libido max sex libido increase best nootropics testosterone tablets semen volumizer rseven male enhancement reviews semen increase what do nitroglycerin pills do supercharge male enhancement uk everest male testosterone booster