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Low Dose Naltrexone in Dermatology

Title
Low Dose Naltrexone in Dermatology
Publication Type
Journal Article
Research Type
Human
Reported as
Review
Date
March 01, 2019
Authors
Joanna Jaros, Peter Lio
Institution
University of Illinois, Northwestern University
Link
Abstract

Low-dose naltrexone (LDN) has been successfully studied as an immunomodulatory and anti-inflammatory therapy in a wide range of conditions including Crohn’s disease, fibromyalgia, major depressive disorder, cancer, chronic regional pain syndrome, Charcot-Marie-Tooth, and multiple sclerosis.1-5 Recently, off label LDN has been shown to improve dermatologic conditions such as systemic sclerosis, Hailey-Hailey Disease, lichen planopilaris, and guttate psoriasis.6-9 In this article, we examine the existing evidence for use of LDN in skin disease and discuss its potential application in the treatment of atopic dermatitis (AD).