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Research

Low-dose naltrexone: a unique treatment for amyopathic dermatomyositis

Title
Low-dose naltrexone: a unique treatment for amyopathic dermatomyositis
Publication Type
Journal Article
Research Type
Human
Reported as
Case Report/Series/Restrospective Study
Date
June 01, 2019
Authors
Albert P. Manudhane, Kory P. Schrom, Harib H. Ezaldein, James A. Armile
Institution
Brown University Warren Alpert Medical School, University Hospitals Cleveland Medical Center, Case Western Reserve University, Lake Erie College of Osteopathic Medicine
Link
Abstract

Gottron papules, a heliotrope rash, scalp and extremity erythema, pruritus, and fatigue are the characteristic signs and symptoms of amyopathic dermatomyositis (ADM). Amyopathic dermatomyositis is considered a distinct entity from dermatomyositis (DM) because the characteristic muscle weakness and muscle enzyme elevations of DM are absent in ADM. With respects to treatment, ADM treatments have traditionally included topical corticosteroids and/or systemic immunosuppressants and immunomodulators. Herein we present a patient with refractory ADM that was responsive to low-dose naltrexone therapy