Find us on:

Research

Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy

Title
Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy
Publication Type
Journal Article
Research Type
human,animal,lab
Reported as
Review
Date
August 09, 2019
Authors
Ruizhe Wang, Yi Zhang, Fengping Shan
Institution
China Medical University
Link
Abstract
 

Endogenous opioids are neuro-peptides with multifunctional properties. Historically, opioids are used to mediate pain; however, excess opiate consumption can lead to addiction. One endogenous opioid, methionine enkephalin (MENK), was reported to modulate cell growth, MENK was identified as an opioid growth factor (OGF) that interacts with the OGF receptor (OGFr) and regulates cell proliferation. Further, opioid antagonists, including naltrexone and naloxone are widely used to reverse drug and alcohol overdoses. Naltrexone (NTX) acts on all opioid receptors, blocking the interaction between OGF and OGFr, and thus influencing cell growth. During the last decades, insights have been made concerning the interaction between OGF and OGFr, confirming that both opioids and opioid antagonists have an important role in balancing host homeostasis, host immunity and mediating cancer therapy. This review provides insight into the interactions between OGF and OGFr in the treatment of cancers.