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Hailey-Hailey disease treated successfully with naltrexone and magnesium.

Title
Hailey-Hailey disease treated successfully with naltrexone and magnesium.
Publication Type
Journal Article
Research Type
Human
Reported as
Case Report/Series/Restrospective Study
Date
August 29, 2019
Authors
Ali Alajmi, Abdulhadi Jfri, Audrey Lovett
Institution
McGill University Health Centre
Link
Abstract

Hailey-Hailey disease (HHD), or benign familial pemphigus, is an autosomal dominant genodermatosis that usually presents between the second and fourth decades of life as painful blisters and erosions in the intertriginous areas. It is characterized by a remitting, relapsing course, and recurrent episodes of superinfection. HHD is caused by mutations in the ATP2C1 gene.

Although HHD is not life threatening, it has a significant negative impact on patient quality of life. Many treatments exist, but none is highly effective. We report a case of a patient with recalcitrant HHD dramatically improving with the combination of low dose naltrexone and magnesium chloride supplementation.