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Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review.

Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review.
Publication Type
Journal Article
Research Type
Reported as
Case Report/Series/Restrospective Study
August 10, 2020
M. Sousa Gomes, J .Araújo Pereira, V. Trocado, JP Prata, V. Teixeira, P. Pinheiro
University of Minho; Hospital Particular Viana do Castelo

PURPOSE: To report a case of vulvar familial benign pemphigus, or Hailey-Hailey disease, treated successfully with low-dose naltrexone and to review the current literature.

METHODS: We report a case of a 71-year-old white woman with vulvar Hailey-Hailey disease recalcitrant to topical corticosteroids. After treatment with low-dose naltrexone, 3 mg nightly was initiated, the lesions began to heal and 5 months later her skin showed no lesions. A literature review on the use of low-dose naltrexone for Hailey-Hailey disease was performed. We searched the PubMed/MEDLINE databases for previous case reports using the key words ''Pemphigus, Benign Familial'' and ''naltrexone"". RESULTS: We found 35 more cases of Hailey-Hailey disease treated with naltrexone, showing promising results, reported until January 2020, with no major adverse effects.

CONCLUSION: Low-dose naltrexone may represent a cost-effective and successful treatment modality in nongeneralized Hailey-Hailey disease without serious adverse effects. Future prospective studies are needed to investigate this interesting therapeutic option.

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