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Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone

Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone
Publication Type
Journal Article
Research Type
Reported as
Case Report/Series/Restrospective Study
November 01, 2020
Michael M, Benjamin MW, Shannon CT
Honor Health/Affiliated Dermatology; Larkin Community Hospital, Oakview Dermatology

Hailey-Hailey (HHD), or benign familial chronic pemphigus disease, is a rare autosomal dominant blistering disorder characterized by recurrent vesicles that erode and macerate into weeping and crusting plaques. HHD has been shown to be resistant to several treatment options. Although not yet approved as a treatment for HHD, recent reports have suggested the use of low-dose naltrexone (LDN) as a successful treatment option for controlling recalcitrant HHD. We present a case of a 50-year-old woman with a 20-year history of biopsy-confirmed HHD with recurrent painful and pruritic vesicles and plaques. The patient developed significant clinical improvement of the cutaneous lesions with LDN treatment after only 26 days of treatment. It is important for dermatologists to consider LDN as a viable treatment option for HHD, especially in recalcitrant patients. We suggest this novel treatment as a rapidly effective option to resistant HHD.

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