Find us on:

Research

Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with Neuropathic Corneal Pain

Title
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with Neuropathic Corneal Pain
Publication Type
Journal Article
Research Type
Human
Reported as
Case Report/Series/Restrospective Study
Date
January 12, 2021
Authors
G. Dieckmann, MC Ozmen, SM Cox, RC Engert, P. Hamrah
Institution
Tufts University School of Medicine
Link
Abstract

PURPOSE: Neuropathic corneal pain (NCP) is caused, by damage or disease of the somatosensory nervous system that innervates the cornea and presents with symptoms of pain or persistent unpleasant sensations, such as burning, dryness, or light sensitivity. This retrospective study aims to assess the efficacy and tolerability of low-dose naltrexone (LDN) in refractory NCP patients.

METHODS: Fifty-nine NCP patients with a centralized component treated with oral LDN 4.5  mg at bedtime for at least four weeks were identified. Thirty out of 59 patients who had a baseline pain score ≥4 on the visual analogue scale had completed the ocular pain assessment survey and presented persistent pain despite instillation of topical anesthetic, were included. Changes in pain scores, comorbidities, side effects, among others, were analyzed. Change in ocular pain scores (scale 0-10) and quality of life (QoL) scores (scale 0-100%) were the main endpoints.

RESULTS: Mean age (years ± SD) was 45.60 ± 19.30 with a white (80.00%) female (73.33%) predominance. Duration of LDN use was 14.87 ± 11.25 months, and the duration of NCP before treatment was 17.53 ± 17.29 months. Eight patients used LDN as monotherapy, whereas the remaining used it as an adjunct therapy. LDN resulted in a 49.22% decrease in mean pain score from 6.13 ± 1.93 to 3.23 ± 2.60 (p < 0.001. Mean QoL scores by the ocular pain assessment survey were 5.84 ± 2.57 at the first visit and improved to 3.77 ± 2.91 at the last visit (p = 0.023). Common side effects were vivid dreams, headache, and stomachache.

CONCLUSION: LDN was effective and well tolerated either as an adjunct therapy for NCP treatment.

weekly workout plan for weight loss newest prescription weight loss pill best beachbody program for weight loss new celebrity diet pills vega protein powder weight loss weight loss surgery boston fat for weight loss neicy nash weight loss healthy soups for weight loss dr bob weight loss pills 40 year old male weight loss workout ketogenic diet fast weight loss weight loss and apple cider vinegar quick weight loss program details 3 day full body workout for weight loss earheart healthy weight loss coupon gluten free weight loss plans non fda approved weight loss pills kathy griffin weight loss medical weight loss locations valley weight loss clinic where can i buy dexatrim peloton cycle weight loss garcinia cambogia diet pills reviews easy weight loss diet plans freshly weight loss blue diet pills sprinting for weight loss diet pills doctors prescribe chakras weight loss abcuts diet pills pink weight loss pills diet pills without prescriptions x weight loss water weight loss quick do keto pills really work cvs cleanse weight loss clinics los angeles

phoenix vape lost vape dna 200 flavrx vape pen smok alien user guide firefly vape review installing vapor barrier in crawl space smok mico uptown vape vape gallery greenville sc gas vapor engine kit vicks vapor rub on cotton ball in ear 200w ecig ecig tank leaking kangertech subtank leaking dr vape juice variable mod vape fruit monsta vape juice blow one vape pen what is mg level in vape juice oil cartridges for vape pen vaping glycerin rta sub ohm tank vaping distilled water xhale vape best 2 battery vape mod top 10 e juice vape shop starter kit rose gold uwell drip tip only best vape mods for 2016 does vaping set off fire alarms smok alien mod wrap top e liquid brands uwell crown drip top how to vape concentrates voopoo drag mini wattage vaping stores san antonio how to take apart voopoo drag nani competition vapes

how to get sexually aroused best online pharmacy reviews best hard pills pills tablets growing dicks finasteride reviews size of dicks mens vitality supplements big dick medicine how to get a bigger but naturally penis suction pumps vasodilators foods average penis sie does vimax works standard penis size enhancerx pill jelqing results 2020 pills to make your dick grow energy pills for men andro 400 testosterone reviews viagra ebay extreme penis enlargement is revatio the same as viagra finasteride brand name alcohol and erections ways to have better sex natural rights definition quizlet terazosin vs flomax limp penis pics low sexual desire fate watch order reddit penis enlargement exercise benefits of testosterone work my cock make dick bigger pills does masturbation cause ed most popular male enhancement pills 9000 times 12

cbd and thc oil cb1 and cb2 receptors cbd is cbd oil legal in ohio 2017 celebrex coupons 2015 cbd and adhd research cbd oil and parkinsons cbd oil 10000 mg expertise definicion sacred body cbd highlife smoke shop cbd may help is cbd oil legal in alabama hemp oil and cbd the same cbd oil best brand crohns disease cbd oil oxygen plus amazon hemp is cbd oil and cream prescribed by doctors smoking bowl amazon full spectrum cbd oil review how to use sativa oil heart reaction memes marijuano meme cbd oil alaska cdg type 1p marijuana and constipation smok alien canada cheap cbd seeds cbd 06 international city medical grade thc cbd dab oil shatter extraction does cbd oil help joint pain smoking kratom cbd oil where is it legal what does cbd vape oil do to you does the fda approve cbd oil entourage effect cbd thc will medicare pay for cbd oil for autism cpr course sydney cbd