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Research

Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer

Title
Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer
Publication Type
Journal Article
Research Type
Human
Reported as
Review
Date
January 26, 2021
Authors
RD Couto, BJD Fernandes
Institution
Federal University of Bahia
Link
Abstract

Naltrexone (NTX) is an opioid antagonist that inhibits cell proliferation in vivo when administered in low doses. Naltrexone in low doses are able to reduce tumor growth by interfering with cell signalling as well as by modifying the immune system. It acts as an opioid growth factor receptor (OGFr) antagonist and the OGF-OGFr axis is an inhibitory biological pathway present in human cancer cells and tissues, being a target for treatment with naltrexone low-dose (LDN). Clinical trials have proposed a unique mechanism(s) allowing LDN to affect tumors. LDN shows promising results for people with primary cancer of the bladder, breast, liver, lung, lymph nodes, colon and rectum. This short review provides further evidence to support the role of LDN as an anticancer agent.

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