Find us on:


Low-Dose Naltrexone Use for Patients with Complex Regional Pain Syndrome: A Systematic Literature Review

Low-Dose Naltrexone Use for Patients with Complex Regional Pain Syndrome: A Systematic Literature Review
Publication Type
Journal Article
Research Type
Reported as
July 01, 2021
A. Soin, Y. Soin, T. Dann, R. Buenaventura, K. Ferguson, S. Atluri, H. Sachdeva, G. Sudarshan, H. Akbik, J. Italiano
Wright State University; Ohio Pain Clinic; Pain Evaluation Management Center of Ohio; Pain Relief of Dayton; Aspirus Health Care of Wisconsin; Interventional Spine Specialists of Cincinnati; University of Cincinnati; Cincinnati Comprehensive Pain Center

BACKGROUND: Complex regional pain syndrome is a rare, neuropathic disorder that affects fewer than 200,000 individuals in the United States annually. Current treatments often focus on pain management and fall short of relieving symptoms of pain and dystonia in patients.

OBJECTIVE: The goal of this systematic qualitative review is to evaluate the evidence for the use of low-dose naltrexone in the treatment of chronic pain syndromes.

STUDY DESIGN: This is a systematic review.

METHODS: PubMed, Embase, and Web of Science were searched for articles containing the keywords "low-dose naltrexone"AND ("pain" OR "chronic pain" OR "fibromyalgia" OR "complex regional pain syndrome" OR "neuropathic pain" OR "nociceptive pain") between 1950 and July 17, 2020. A total of 30 publications were systematically reviewed. Exclusion criteria were articles that were unavailable in English, focused on acute pain only, and evaluated only animal models. Case studies were included for the purposes of our qualitative review.

RESULTS: Out of 29 articles, we reviewed 11 prospective studies, 10 case studies, 3 systematic reviews, 2 retrospective studies, 2 simulation models, and one combination study. Articles focused on chronic pain syndromes as well as painful rheumatologic disorders and neurological disorders. We found that low-dose naltrexone treatment was positively associated with symptom relief in patients experiencing chronic pain, dystonia, and sleep disturbances.

LIMITATIONS: Due to the limited number of available articles focusing on the treatment of complex regional pain syndrome with low-dose naltrexone, the majority of studies analyzed focused on other chronic pain syndromes.

CONCLUSIONS: There is a need for additional prospective and interventional studies addressing the use of low-dose naltrexone in the treatment of complex regional pain syndrome symptoms.

vape no A Tag

foods that aid weight loss california weight loss weight loss smoothie diet dr syverain weight loss clinic teenage weight loss pills 3x diet pills 120 pound weight loss dr quick weight loss celebrity weight loss pills 2015 alcohol abuse weight loss the doctors show weight loss pills cinnamon weight loss reviews prescription diet pills online 100 guaranteed weight loss pills v 3 diet pills diet pills that work fast walmart advocare diet pills side effects boost plus side effects diet pills for women in menopause appetite suppressant without caffeine what is liquid diet for weight loss medical weight loss solution

best libido booster for male penis thickening viagra before and after male enhancement clinic near me drugs that start with a erection herbs men erect penis male enhancement aloe vera king size pills side effects sexy t or d teenage male penis how to decrease sex drive c1 round blue pill penis enlargement pilld ginkgo biloba erectile dysfunction normal flaccid penis quizlet medical terms evernote alternative reddit best dick ever ageless male max review men penuses why is cialis so expensive

cbd and gabapentin rainbow shops review history of cbd cbd capsules reviews rosebud cbd oil canablast cbd cbd vap oil will high cbd hemp oil help with anxiety pain nature cbd can cbd oil cause liver damage can cbd oil help with coughing urban dictionary mood how to take hemp oil orally cbd medicine package insert fda hemp in spanish free epilepsy stuff what does nt stand for in medical terms chiropractic practice for sale florida thc edibles marijuana topical pain relief texas cbd laws 2019