Find us on:

Research

Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment

Title
Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment
Publication Type
Journal Article
Research Type
Human
Reported as
Case Report/Series/Restrospective Study
Date
July 13, 2021
Authors
H. Cabanas, K. Muraki, N. Eaton-Fitch, D.R. Staines, S. Marshall-Gradisnik
Institution
Griffith University, Aichi-Gakuin University
Link
Abstract

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating multi-systemic chronic condition of unknown aetiology classified as an immune dysfunction syndrome and neurological disorder. The discovery of the widely expressed Transient Receptor Potential Melastatin 3 (TRPM3) as a nociceptor channel substantially targeted by certain opioid receptors, and its implication in calcium (Ca2+)-dependent Natural Killer (NK) cell immune functions has raised the possibility that TRPM3 may be pharmacologically targeted to treat characteristic symptoms of ME/CFS. Naltrexone hydrochloride (NTX) acts as an antagonist to the mu (μ)-opioid receptor thus negating its inhibitory function on TRPM3. Based on the benefits reported by patients on their symptoms, low dose NTX (LDN, 3.0-5.0 mg/day) treatment seems to offer some potential benefit suggesting that its effect may be targeted towards the pathomechanism of ME/CFS. As there is no literature confirming the efficacy of LDN for ME/CFS patients in vitro, this study investigates the potential therapeutic effect of LDN in ME/CFS patients. TRPM3 ion channel activity was measured after modulation with Pregnenolone sulfate (PregS) and ononetin in NK cells on 9 ME/CFS patients taking LDN and 9 age- and sex-matched healthy controls using whole-cell patch-clamp technique. We report that ME/CFS patients taking LDN have restored TRPM3-like ionic currents in NK cells. Small ionic currents with a typical TRPM3-like outward rectification were measured after application of PregS, a TRPM3-agonist, in NK cells from patients taking LDN. Additionally, PregS-evoked ionic currents through TRPM3 were significantly modulated by ononetin, a TRPM3-antagonist, in NK cells from ME/CFS patients taking LDN. These data support the hypothesis that LDN may have potential as a treatment for ME/CFS by characterising the underlying regulatory mechanisms of LDN treatment involving TRPM3 and opioid receptors in NK cells. Finally, this study may serve for the repurpose of marketed drugs, as well as support the approval of prospective randomized clinical studies on the role and dose of NTX in treating ME/CFS patients.

charlotte web cbd cbd oil gummy bears ameo cbd patch is the world health organization a scholarly source is cbd the same as hemp oil where do you get cbd oil in fort collins no thc haleighs hope cbd weller cbd massage with cbd oil near me cbd oil vs essential oils cbd store los angeles new you drops cbd cbd companies that give discounts for disability aspire physical therapy la canada monteverde pens review cbd oil with or without food codeine side effects cbd worth it cbd oil press release cbd oil terpenes sativa strains oil cbd koi cbd oil 1000mg best price holistapet cbd oil dosage ace 17 adidas

calculator for weight loss valley medical weight loss moringa powder and weight loss diet pills help lose weight fast glp1 weight loss josh peck weight loss diet loose it weight loss grapefruit juice benefits weight loss the best smoothie for weight loss vshred fat loss extreme reviews weight loss for heart patients diet express weight loss clinic tyler tx rebel wilson weight loss now weight loss plateau breaker music city weight loss cost weight loss sweat suits high blood pressure and diet pills 3 day cleanses weight loss about fastin diet pills birth control for pcos and weight loss best diet for losing fat vincent d onofrio weight loss thrive keto pills 2018 diet pills

ed doctor near me penile nerve damage symptoms silicone dick penus definition penis growth injection viagra vs cialis price diabetes and viagra how to sexually arouse a woman facial sex young teen boys dicks a sexual definition edex injection how to increase girth size fast what to take for ed revboost where to buy boy penis sizes super t performix review all types of penis 1 male enlargement pills penice pump increase volume of ejaculate psychology 2 quizlet male enhancement clinic near me v maxx male enhancement reviews

vape no A Tag