Find us on:

Research

Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment

Title
Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment
Publication Type
Journal Article
Research Type
Human
Reported as
Case Report/Series/Restrospective Study
Date
July 13, 2021
Authors
H. Cabanas, K. Muraki, N. Eaton-Fitch, D.R. Staines, S. Marshall-Gradisnik
Institution
Griffith University, Aichi-Gakuin University
Link
Abstract

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating multi-systemic chronic condition of unknown aetiology classified as an immune dysfunction syndrome and neurological disorder. The discovery of the widely expressed Transient Receptor Potential Melastatin 3 (TRPM3) as a nociceptor channel substantially targeted by certain opioid receptors, and its implication in calcium (Ca2+)-dependent Natural Killer (NK) cell immune functions has raised the possibility that TRPM3 may be pharmacologically targeted to treat characteristic symptoms of ME/CFS. Naltrexone hydrochloride (NTX) acts as an antagonist to the mu (μ)-opioid receptor thus negating its inhibitory function on TRPM3. Based on the benefits reported by patients on their symptoms, low dose NTX (LDN, 3.0-5.0 mg/day) treatment seems to offer some potential benefit suggesting that its effect may be targeted towards the pathomechanism of ME/CFS. As there is no literature confirming the efficacy of LDN for ME/CFS patients in vitro, this study investigates the potential therapeutic effect of LDN in ME/CFS patients. TRPM3 ion channel activity was measured after modulation with Pregnenolone sulfate (PregS) and ononetin in NK cells on 9 ME/CFS patients taking LDN and 9 age- and sex-matched healthy controls using whole-cell patch-clamp technique. We report that ME/CFS patients taking LDN have restored TRPM3-like ionic currents in NK cells. Small ionic currents with a typical TRPM3-like outward rectification were measured after application of PregS, a TRPM3-agonist, in NK cells from patients taking LDN. Additionally, PregS-evoked ionic currents through TRPM3 were significantly modulated by ononetin, a TRPM3-antagonist, in NK cells from ME/CFS patients taking LDN. These data support the hypothesis that LDN may have potential as a treatment for ME/CFS by characterising the underlying regulatory mechanisms of LDN treatment involving TRPM3 and opioid receptors in NK cells. Finally, this study may serve for the repurpose of marketed drugs, as well as support the approval of prospective randomized clinical studies on the role and dose of NTX in treating ME/CFS patients.

drinking for weight loss zach galifianakis 2015 weight loss motivational quote weight loss anti anxiety medication weight loss vitamin b for weight loss when does weight loss show morgan westbrook weight loss george wendt weight loss 1400 calories a day weight loss genomma lab weight loss pills weight loss plateau breaker pomegranates weight loss uc weight loss list of pills weight loss before and after nude mild weight loss pills how to use shakeology for weight loss is almond milk good for weight loss pescatarian diet weight loss pro image diet pills weight loss gastonia nc avocado and weight loss diet cleanses for weight loss sensa weight loss take 2 day diet pills biblical solution to weight loss ephedrine diet pills for sale uk tdee calculator weight loss slim tech diet pills lemon and honey for weight loss water pills to lose weight fast weight loss smothies

how to use cbd oil for erectile dysfunction what is the best full spectrum cbd oil cbd prescription high cbd oil treatment progressive nuclear palso does cbd help with depression pet action plus ingredients etst cbd oil aa pg 417 cbd oil for sleep dosage hemp oil plus does cbd really work for anxiety cbd oil moore ok cbd testing lab near me cbd oil and infection 150 mg cbd how long does cbd last where to buy cbd oil capsules near me que significa its sublingual cbd tincture hemp oil cbd spray hemp gummies benefits cbd seeds colorado when to use were and was cbd hemp oil 300 level products work cbd bank dubai how cbd is made sol cbd oil cure all negative side effects cbd oil use endow in a sentence diabetes 101

what happens if you take viagra real penile enhancement how viagra work define erecting mail medicine fun ways to masturbate men huge cock pump white pimples on penile head male health supplement is there a way to get a bigger penis progentra real reviews pain enhancer endurolast male enhancement triple action pill virectin reviews gnc progentra reviews pictures that make you hard masturbating tips for men epimedium supplement t bomb extreme yohimbine for ed best way to build testosterone ptsd erectile dysfunction male enhancement you can buy stores what does boner means why is my penis not growing desires definition foods that help erectile dysfunction alpha warhead is a bigger penis better tribulus terrestris vitamin shoppe what do testosterone supplements do

vape no A Tag