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Topical Therapeutic Options in Corneal Neuropathic Pain

Title
Topical Therapeutic Options in Corneal Neuropathic Pain
Publication Type
Journal Article
Research Type
Human
Reported as
Review
Date
January 31, 2022
Authors
J Nortey, D Smith, GD Seitzman, JA Gonzales
Institution
University of North Carolina; University of California, San Francisco; A&O Compounding Pharmacy
Link
Abstract

Corneal neuropathic pain can be difficult to treat, particularly due to its lack of response to standard dry eye therapies. We describe a variety of topical therapeutic options that are available to treat corneal neuropathic pain with a significant or primary peripheral component. We also describe possible mechanisms of action for such topical therapies. Recent Findings: Topical corticosteroids and blood-derived tear preparations can be helpful. Newer therapies, including topical lacosamide and low-dose naltrexone are emerging therapeutic options that may also be considered. Summary: Corneal neuropathic pain with a significant peripheral component may be managed with a variety of topical therapeutic options.

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